PROSITE documentation PDOC00385
Ribosomal protein L3 signature


Ribosomal protein L3 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase center of the ribosome. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2,3,4], groups:

  • Eubacterial L3.
  • Red algal L3.
  • Cyanelle L3.
  • Archaebacterial Halobacterium marismortui HmaL3 (HL1).
  • Yeast L3 (also known as trichodermin resistance protein) (gene TCM1).
  • Arabidopsis thaliana L3 (genes ARP1 and ARP2).
  • Mammalian L3 (L4).
  • Mammalian mitochondrial L3.
  • Yeast mitochondrial YmL9 (gene MRPL9).

As a signature pattern, we selected a conserved region located in the central section of these proteins.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L3, PS00474; Ribosomal protein L3 signature  (PATTERN)


1AuthorsArndt E. Kroemer W. Hatakeyama T.
TitleOrganization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui.
SourceJ. Biol. Chem. 265:3034-3039(1990).
PubMed ID2406244

2AuthorsGraack H.-R. Grohmann L. Kitakawa M. Schaefer K.L. Kruft V.
TitleYmL9, a nucleus-encoded mitochondrial ribosomal protein of yeast, is homologous to L3 ribosomal proteins from all natural kingdoms and photosynthetic organelles.
SourceEur. J. Biochem. 206:373-380(1992).
PubMed ID1597181

3AuthorsHerwig S. Kruft V. Wittmann-Liebold B.
TitlePrimary structures of ribosomal proteins L3 and L4 from Bacillus stearothermophilus.
SourceEur. J. Biochem. 207:877-885(1992).
PubMed ID1499563

4AuthorsOtaka E. Hashimoto T. Mizuta K. Suzuki K.
SourceProtein Seq. Data Anal. 5:301-313(1993).

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