PROSITE documentation PDOC00432
Gonadotropin-releasing hormones signature


The gonadotropin-releasing hormones (GnRH) (gonadoliberin) [1] are a family of peptides that play a pivotal role in reproduction. The main function of GnRH is to act on the pituitary to stimulate the synthesis and secretion of luteinizing and follicle-stimulating hormones, but GnRH also acts on the brain, retina, sympathetic nervous system, gonads and placenta in certain species. There seems to be at least three forms of GnRH. The second form is expressed in midbrain and seems to be widespread. The third form has only been found so far in fish.

GnRH is a C-terminal amidated decapeptide processed from a larger precursor protein. Four of the ten residues are perfectly conserved in all species where GnRH has been sequenced.

Expert(s) to contact by email:

Eisen J.A.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GNRH, PS00473; Gonadotropin-releasing hormones signature  (PATTERN)


1AuthorsSherwood N.
SourceTrends Neurosci. 10:129-132(1987).

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