PROSITE documentation PDOC00437
Pathogenesis-related proteins Bet v I family signature


A number of plant proteins, which all seem to be involved in pathogen defense response, are structurally related [1,2,3]. These proteins are:

  • Bet v I, the major pollen allergen from white birch. Bet v I is the main cause of type I allergic reactions in Europe, North America and USSR.
  • Aln g I, the major pollen allergen from alder.
  • Api G I, the major allergen from celery.
  • Car b I, the major pollen allergen from hornbeam.
  • Cor a I, the major pollen allergen from hazel.
  • Mal d I, the major pollen allergen from apple.
  • Asparagus wound-induced protein AoPR1.
  • Kidney bean pathogenesis-related proteins 1 and 2.
  • Parsley pathogenesis-related proteins PR1-1 and PR1-3.
  • Pea disease resistance response proteins pI49, pI176 and DRRG49-C.
  • Pea abscisic acid-responsive proteins ABR17 and ABR18.
  • Potato pathogenesis-related proteins STH-2 and STH-21.
  • Soybean stress-induced protein SAM22.

These proteins are thought to be intracellularly located. They contain from 155 to 160 amino acid residues. As a signature pattern, we selected a conserved region located in the third quarter of these proteins.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PATHOGENESIS_BETVI, PS00451; Pathogenesis-related proteins Bet v I family signature  (PATTERN)


1AuthorsBreiteneder H. Pettenburger K. Bito A. Valenta R. Kraft D. Rumpold H. Scheiner O. Breitenbach M.
TitleThe gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene.
SourceEMBO J. 8:1935-1938(1989).
PubMed ID2571499

2AuthorsCrowell D.N. John M.E. Russell D. Amasino R.M.
TitleCharacterization of a stress-induced, developmentally regulated gene family from soybean.
SourcePlant Mol. Biol. 18:459-466(1992).
PubMed ID1371403

3AuthorsWarner S.A.J. Scott R. Draper J.
TitleCharacterisation of a wound-induced transcript from the monocot asparagus that shares similarity with a class of intracellular pathogenesis-related (PR) proteins.
SourcePlant Mol. Biol. 19:555-561(1992).
PubMed ID1627770

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