We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00442Corticotropin-releasing factor family signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00442
Description
Corticotropin-releasing factor (CRF) (corticoliberin) [1] is a hormone from the hypothalamus that regulates the release of corticotropin (ACTH) from the pituitary gland. CRF is evolutionary related to a number of other active peptides which are listed below.
- Urocortin (Ucn) [2], a brain mammalian peptide with corticotropin-releasing factor activity.
- Urotensin 1 from the urophysis of fish. Like CRF and Ucn, it acts in ACTH secretion.
- Sauvagine from frog skin, a peptide with a potent hypotensive action that elicits a diuretic effect.
- Diuretic hormone (DH) (or diuretic peptide (DP) from a variety of insects. DH is involved in the regulation of fluid secretion [3].
All these hormones are peptides of about 40 amino acid residues which are C-terminally amidated and processed from a larger precursor protein. We derived a signature pattern of conserved residues, running from position 4 to 19 in these peptides.
Last update:July 1999 / Pattern and text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Lederis K.P. Okawara Y. Richter D. Morley S.D. |
| Title | Evolutionary aspects of corticotropin releasing hormones. | |
| Source | Prog. Clin. Biol. Res. 342:467-472(1990). | |
| PubMed ID | 2200028 |
| 2 | Authors | Vaughan J. Donaldson C. Bittencourt J. Perrin M.H. Lewis K. Sutton S. Chan R. Turnbull A.V. Lovejoy D. Rivier C. |
| Title | Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. | |
| Source | Nature 378:287-292(1995). | |
| PubMed ID | 7477349 | |
| DOI | 10.1038/378287a0 |
| 3 | Authors | Clottens F.L. Holman G.M. Coast G.M. Totty N.F. Hayes T.K. Kay I. Mallet A.I. Wright M.S. Chung J.S. Truong O. |
| Title | Isolation and characterization of a diuretic peptide common to the house fly and stable fly. | |
| Source | Peptides 15:971-979(1994). | |
| PubMed ID | 7991460 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.