PROSITE documentation PDOC00442Corticotropin-releasing factor family signature
Description
Corticotropin-releasing factor (CRF) (corticoliberin) [1] is a hormone from the hypothalamus that regulates the release of corticotropin (ACTH) from the pituitary gland. CRF is evolutionary related to a number of other active peptides which are listed below.
- Urocortin (Ucn) [2], a brain mammalian peptide with corticotropin-releasing factor activity.
- Urotensin 1 from the urophysis of fish. Like CRF and Ucn, it acts in ACTH secretion.
- Sauvagine from frog skin, a peptide with a potent hypotensive action that elicits a diuretic effect.
- Diuretic hormone (DH) (or diuretic peptide (DP) from a variety of insects. DH is involved in the regulation of fluid secretion [3].
All these hormones are peptides of about 40 amino acid residues which are C-terminally amidated and processed from a larger precursor protein. We derived a signature pattern of conserved residues, running from position 4 to 19 in these peptides.
Last update:July 1999 / Pattern and text revised.
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References
| 1 | Authors | Lederis K.P. Okawara Y. Richter D. Morley S.D. |
| Title | Evolutionary aspects of corticotropin releasing hormones. | |
| Source | Prog. Clin. Biol. Res. 342:467-472(1990). | |
| PubMed ID | 2200028 |
| 2 | Authors | Vaughan J. Donaldson C. Bittencourt J. Perrin M.H. Lewis K. Sutton S. Chan R. Turnbull A.V. Lovejoy D. Rivier C. |
| Title | Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. | |
| Source | Nature 378:287-292(1995). | |
| PubMed ID | 7477349 | |
| DOI | 10.1038/378287a0 |
| 3 | Authors | Clottens F.L. Holman G.M. Coast G.M. Totty N.F. Hayes T.K. Kay I. Mallet A.I. Wright M.S. Chung J.S. Truong O. |
| Title | Isolation and characterization of a diuretic peptide common to the house fly and stable fly. | |
| Source | Peptides 15:971-979(1994). | |
| PubMed ID | 7991460 |
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