PROSITE documentation PDOC00446
Seminal vesicle protein II repeats signature


Seminal vesicle protein II (SVP-II) [1] is one of the six major secretory proteins secreted by rat seminal vesicle. It is a clotting protein that serves as the substrate in the formation of the copulatory plug. Covalent clotting of this protein is catalyzed by a transglutaminase and involves the formation of γ-glutamyl-epsilon-lysine crosslinks. SVS-II sequence contains thirteen repeats of a thirteen amino acid residue domain which is probably involved in the cross-linking. There are a number of invariant residues in this domain, four of them (two lysines and two glutamines) probably participate in the cross-links. The pattern we have developed comprises positions 2 to 12 of the domain and includes the four putative cross-linking residues.

Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SVP_II, PS00515; Seminal vesicle protein II repeats signature  (PATTERN)


1AuthorsHarris S.E. Harris M.A. Johnson C.M. Bean M.F. Dodd J.G. Matusik R.J. Carr S.A. Crabb J.W.
TitleStructural characterization of the rat seminal vesicle secretion II protein and gene.
SourceJ. Biol. Chem. 265:9896-9903(1990).
PubMed ID2351680

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