PROSITE documentation PDOC00446Seminal vesicle protein II repeats signature
Seminal vesicle protein II (SVP-II) [1] is one of the six major secretory proteins secreted by rat seminal vesicle. It is a clotting protein that serves as the substrate in the formation of the copulatory plug. Covalent clotting of this protein is catalyzed by a transglutaminase and involves the formation of γ-glutamyl-epsilon-lysine crosslinks. SVS-II sequence contains thirteen repeats of a thirteen amino acid residue domain which is probably involved in the cross-linking. There are a number of invariant residues in this domain, four of them (two lysines and two glutamines) probably participate in the cross-links. The pattern we have developed comprises positions 2 to 12 of the domain and includes the four putative cross-linking residues.
Last update:May 2004 / Text revised.
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1 | Authors | Harris S.E. Harris M.A. Johnson C.M. Bean M.F. Dodd J.G. Matusik R.J. Carr S.A. Crabb J.W. |
Title | Structural characterization of the rat seminal vesicle secretion II protein and gene. | |
Source | J. Biol. Chem. 265:9896-9903(1990). | |
PubMed ID | 2351680 |
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