We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00448Ribonuclease III family signature and profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00448
Description
Prokaryotic ribonuclease III (EC 3.1.26.3) (gene rnc) [1] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related [2] to the following proteins:
- Fission yeast pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development.
- Yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites.
- Caenorhabditis elegans hypothetical protein F26E4.13.
- Paramecium bursaria chlorella virus 1 protein A464R.
- Synechocystis strain PCC 6803 hypothetical protein slr0346.
- Fission yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain.
- Caenorhabditis elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c.
These proteins share regions of sequence similarity; one of which is a highly conserved stretch of 9 residues which we use as a signature pattern.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Nashimoto H. Uchida H. |
| Title | DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations. | |
| Source | Mol. Gen. Genet. 201:25-29(1985). | |
| PubMed ID | 3903434 |
| 2 | Authors | Mian I.S. |
| Title | Comparative sequence analysis of ribonucleases HII, III, II PH and D. | |
| Source | Nucleic Acids Res. 25:3187-3195(1997). | |
| PubMed ID | 9241229 |
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