PROSITE documentation PDOC00450Interleukin-10 family signature
Description
Interleukin-10 (IL-10) [1] is a protein that inhibits the synthesis of a number of cytokines, including IFN-γ, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.
Structurally, IL-10 is a protein of about 160 amino acids that contain four conserved cysteines involved in disulfide bonds [2].
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xxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxx
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'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
IL-10 belongs to a family that includes:
- Epstein-Barr virus BCRF1 protein, which inhibits the synthesis of γ- interferon.
- Equine herpesvirus type 2 protein E7.
- Interleukin-19.
- Interleukin-20.
- Interleukin-22.
- Interleukin-24 (mda-7).
- Human protein AK155.
As a pattern, we selected a region around the second cysteine of IL-10.
Last update:April 2006 / Pattern revised.
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Technical section
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References
| 1 | Authors | Moore K.W. O'Garra A. de Waal Malefyt R. Vieira P. Mosmann T.R. |
| Title | Interleukin-10. | |
| Source | Annu. Rev. Immunol. 11:165-190(1993). | |
| PubMed ID | 8386517 | |
| DOI | 10.1146/annurev.iy.11.040193.001121 |
| 2 | Authors | Zdanov A. Schalk-Hihi C. Gustchina A. Tsang M. Weatherbee J. Wlodawer A. |
| Title | Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. | |
| Source | Structure 3:591-601(1995). | |
| PubMed ID | 8590020 |
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