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PROSITE documentation PDOC00450

Interleukin-10 family signature





Description

Interleukin-10 (IL-10) [1] is a protein that inhibits the synthesis of a number of cytokines, including IFN-γ, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.

Structurally, IL-10 is a protein of about 160 amino acids that contain four conserved cysteines involved in disulfide bonds [2].

                +-------------------------------------+
                |                  *****              |
     xxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxx
                                    |                   |
                                    +-------------------+
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

IL-10 belongs to a family that includes:

  • Epstein-Barr virus BCRF1 protein, which inhibits the synthesis of γ- interferon.
  • Equine herpesvirus type 2 protein E7.
  • Interleukin-19.
  • Interleukin-20.
  • Interleukin-22.
  • Interleukin-24 (mda-7).
  • Human protein AK155.

As a pattern, we selected a region around the second cysteine of IL-10.

Last update:

April 2006 / Pattern revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

INTERLEUKIN_10, PS00520; Interleukin-10 family signature  (PATTERN)


References

1AuthorsMoore K.W. O'Garra A. de Waal Malefyt R. Vieira P. Mosmann T.R.
TitleInterleukin-10.
SourceAnnu. Rev. Immunol. 11:165-190(1993).
PubMed ID8386517
DOI10.1146/annurev.iy.11.040193.001121

2AuthorsZdanov A. Schalk-Hihi C. Gustchina A. Tsang M. Weatherbee J. Wlodawer A.
TitleCrystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
SourceStructure 3:591-601(1995).
PubMed ID8590020



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