We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00450Interleukin-10 family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00450
Description
Interleukin-10 (IL-10) [1] is a protein that inhibits the synthesis of a number of cytokines, including IFN-γ, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells.
Structurally, IL-10 is a protein of about 160 amino acids that contain four conserved cysteines involved in disulfide bonds [2].
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| ***** |
xxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxx
| |
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'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
IL-10 belongs to a family that includes:
- Epstein-Barr virus BCRF1 protein, which inhibits the synthesis of γ- interferon.
- Equine herpesvirus type 2 protein E7.
- Interleukin-19.
- Interleukin-20.
- Interleukin-22.
- Interleukin-24 (mda-7).
- Human protein AK155.
As a pattern, we selected a region around the second cysteine of IL-10.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Moore K.W. O'Garra A. de Waal Malefyt R. Vieira P. Mosmann T.R. |
| Title | Interleukin-10. | |
| Source | Annu. Rev. Immunol. 11:165-190(1993). | |
| PubMed ID | 8386517 | |
| DOI | 10.1146/annurev.iy.11.040193.001121 |
| 2 | Authors | Zdanov A. Schalk-Hihi C. Gustchina A. Tsang M. Weatherbee J. Wlodawer A. |
| Title | Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma. | |
| Source | Structure 3:591-601(1995). | |
| PubMed ID | 8590020 |
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