We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00457Ribosomal protein S4e signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00457
Description
A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists of:
- Mammalian S4 [1]. Two highly similar isoforms of this protein exist : one coded by a gene on chromosome Y, and the other on chromosome X.
- Plant cytoplasmic S4 [2]
- Yeast S7 (YS6).
- Archebacterial S4e.
These proteins have 233 to 264 amino acids. As a signature pattern, we selected a highly conserved stretch of 15 residues in their N-terminal section. Four positions in this region are positively charged residues.
Last update:July 1999 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Fisher E.M. Beer-Romero P. Brown L.G. Ridley A. McNeil J.A. Lawrence J.B. Willard H.F. Bieber F.R. Page D.C. |
| Title | Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. | |
| Source | Cell 63:1205-1218(1990). | |
| PubMed ID | 2124517 |
| 2 | Authors | Braun H.P. Emmermann M. Mentzel H. Schmitz U.K. |
| Title | Primary structure and expression of a gene encoding the cytosolic ribosomal protein S4 from potato. | |
| Source | Biochim. Biophys. Acta 1218:435-438(1994). | |
| PubMed ID | 8049269 |
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