PROSITE documentation PDOC00475
Bacterioferritin signature


Bacterioferritin (BFR) [1,2] is a prokaryotic iron-storing protein that may perform analogous functions in iron detoxification and storage as that of eukaryotic ferritins. BFR is also known as cytochrome b-1, b-557, b-557.5, or b-559 in various bacterial species.

BFR is an oligomer composed of 24 identical subunits that contains protoheme IX in addition to the non-heme iron core. The two axial ligands for the heme group iron have been shown [3] to be methionine residues.

As a signature pattern we selected the conserved N-terminal extremity of BFR.

Last update:

December 2001 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

BACTERIOFERRITIN, PS00549; Bacterioferritin signature  (PATTERN)


1AuthorsAndrews S.C. Smith J.M.A. Guest J.R. Harrison P.M.
TitleGenetic and structural characterization of the bacterioferritin of Escherichia coli.
SourceBiochem. Soc. Trans. 18:658-659(1990).
PubMed ID2276500

2AuthorsAndrews S.C. Findlay J.B.C. Guest J.R. Harrison P.M. Keen J.N. Smith J.M.A.
TitlePhysical, chemical and immunological properties of the bacterioferritins of Escherichia coli, Pseudomonas aeruginosa and Azotobacter vinelandii.
SourceBiochim. Biophys. Acta 1078:111-116(1991).
PubMed ID1904771

3AuthorsCheesman M.R. Thomson A.J. Greenwood C. Moore G.R. Kadir F.
TitleBis-methionine axial ligation of haem in bacterioferritin from Pseudomonas aeruginosa.
SourceNature 346:771-773(1990).
PubMed ID2167456

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