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PROSITE documentation PDOC00475Bacterioferritin signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00475
Bacterioferritin (BFR) [1,2] is a prokaryotic iron-storing protein that may perform analogous functions in iron detoxification and storage as that of eukaryotic ferritins. BFR is also known as cytochrome b-1, b-557, b-557.5, or b-559 in various bacterial species.
BFR is an oligomer composed of 24 identical subunits that contains protoheme IX in addition to the non-heme iron core. The two axial ligands for the heme group iron have been shown [3] to be methionine residues.
As a signature pattern we selected the conserved N-terminal extremity of BFR.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Andrews S.C. Smith J.M.A. Guest J.R. Harrison P.M. |
| Title | Genetic and structural characterization of the bacterioferritin of Escherichia coli. | |
| Source | Biochem. Soc. Trans. 18:658-659(1990). | |
| PubMed ID | 2276500 |
| 2 | Authors | Andrews S.C. Findlay J.B.C. Guest J.R. Harrison P.M. Keen J.N. Smith J.M.A. |
| Title | Physical, chemical and immunological properties of the bacterioferritins of Escherichia coli, Pseudomonas aeruginosa and Azotobacter vinelandii. | |
| Source | Biochim. Biophys. Acta 1078:111-116(1991). | |
| PubMed ID | 1904771 |
| 3 | Authors | Cheesman M.R. Thomson A.J. Greenwood C. Moore G.R. Kadir F. |
| Title | Bis-methionine axial ligation of haem in bacterioferritin from Pseudomonas aeruginosa. | |
| Source | Nature 346:771-773(1990). | |
| PubMed ID | 2167456 | |
| DOI | 10.1038/346771a0 |
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