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PROSITE documentation PDOC00504 |
It has been shown [1,2,3] that the following carbohydrate and purine kinases are evolutionary related and can be grouped into a single family, which is known [1] as the 'pfkB family':
All the above kinases are proteins of from 280 to 430 amino acid residues that share a few region of sequence similarity. We have selected two of these regions as signature patterns. The first pattern is based on a region rich in glycine which is located in the N-terminal section of these enzymes; while the second pattern is based on a conserved region in the C-terminal section.
Note:Some bacterial fructokinases belong to the ROK family <PDOC00866>.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Wu L.-F. Reizer A. Reizer J. Cai B. Tomich J.M. Saier M.H. Jr. |
Title | Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. | |
Source | J. Bacteriol. 173:3117-3127(1991). | |
PubMed ID | 1850730 |
2 | Authors | Orchard L.M.D. Kornberg H.L. |
Title | Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus. | |
Source | Proc. R. Soc. Lond., B, Biol. Sci. 242:87-90(1990). | |
PubMed ID | 1981619 |
3 | Authors | Blatch G.L. Scholle R.R. Woods D.R. |
Title | Nucleotide sequence and analysis of the Vibrio alginolyticus sucrose uptake-encoding region. | |
Source | Gene 95:17-23(1990). | |
PubMed ID | 2174811 |