PROSITE documentation PDOC00508Flagella basal body rod proteins signature
Many bacterial species swim actively by means of flagella [1]. The flagella organelle is made of three parts: the basal body, the hook and the filament. The basal body consists of four rings (L,P,S, and M) mounted on a central rod. In Salmonella typhimurium and related organisms the rod has been shown [2] to consist of four different, yet evolutionary related proteins: in the distal portion of the rod there are about 26 subunits of protein flgG and in the proximal portion there are about 6 subunits each of proteins flgB, flgC, and flgF.
These four proteins contain in their N-terminal section a highly conserved asparagine-rich domain that we have used as a signature pattern.
This pattern is also found in:
- Flagella hook protein flgE from Gram-negative bacteria.
- Flagellar hook-associated protein 1 (HAP1) (flgK) from Gram-negative bacteria.
- Flagellar hook-basal body proteins flhO and flhP from Bacillus subtilis.
- The central section of the flagella core protein (flaA) of Borrelia burgdorferi.
December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | MacNab R.M. biology Neidhardt F.C. Ingraham J.L. Low K.B. Magasanik B. |
| Source | (In) Escherichia coli and Salmonella typhimurium: cellular and molecular Schaechter M., Umbarger H.E., Eds., pp70-83, American society for Microbiology, Washington D.C, (1987). |
| 2 | Authors | Homma M. Kutsukake K. Hasebe M. Iino T. Macnab R.M. |
| Title | FlgB, FlgC, FlgF and FlgG. A family of structurally related proteins in the flagellar basal body of Salmonella typhimurium. | |
| Source | J. Mol. Biol. 211:465-477(1990). | |
| PubMed ID | 2129540 |
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