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PROSITE documentation PDOC00508

Flagella basal body rod proteins signature





Description

Many bacterial species swim actively by means of flagella [1]. The flagella organelle is made of three parts: the basal body, the hook and the filament. The basal body consists of four rings (L,P,S, and M) mounted on a central rod. In Salmonella typhimurium and related organisms the rod has been shown [2] to consist of four different, yet evolutionary related proteins: in the distal portion of the rod there are about 26 subunits of protein flgG and in the proximal portion there are about 6 subunits each of proteins flgB, flgC, and flgF.

These four proteins contain in their N-terminal section a highly conserved asparagine-rich domain that we have used as a signature pattern.

This pattern is also found in:

  • Flagella hook protein flgE from Gram-negative bacteria.
  • Flagellar hook-associated protein 1 (HAP1) (flgK) from Gram-negative bacteria.
  • Flagellar hook-basal body proteins flhO and flhP from Bacillus subtilis.
  • The central section of the flagella core protein (flaA) of Borrelia burgdorferi.
Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

FLAGELLA_BB_ROD, PS00588; Flagella basal body rod proteins signature  (PATTERN)


References

1AuthorsMacNab R.M.
Source(In) Escherichia coli and Salmonella typhimurium: cellular and molecular biology, Neidhardt F.C., Ingraham J.L., Low K.B., Magasanik B., Schaechter M., Umbarger H.E., Eds., pp70-83, American society for Microbiology, Washington D.C, (1987).

2AuthorsHomma M. Kutsukake K. Hasebe M. Iino T. Macnab R.M.
TitleFlgB, FlgC, FlgF and FlgG. A family of structurally related proteins in the flagellar basal body of Salmonella typhimurium.
SourceJ. Mol. Biol. 211:465-477(1990).
PubMed ID2129540



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