PROSITE documentation PDOC00509LIF / OSM family signature
On the basis of functional and structural similarities, the following small cytokines can be classified into a single family [1,2]:
- Leukemia inhibitory factor (LIF) (also known as differentiation-stimulating factor). LIF is a mammalian growth factor that controls the differentiation and proliferation of hematopoietic cells as well as those of several other cellular lineages.
- Oncostatin (OSM), a growth regulator produced by a number of mammalian cells lines. OSM is capable of inhibiting the replication of a number of tumor cells.
As a signature pattern for these cytokines, we selected a conserved region in their C-terminal section. This region is centered on a conserved cysteine which has been shown [3], in OSM, to be involved in a disulfide bond.
Note:It has been said [2] that LIF and OSM can be included in the IL-6 family of cytokines (see the relevant entry <PDOC00227>), but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.
Last update:November 1997 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Hilton D.J. |
| Title | LIF: lots of interesting functions. | |
| Source | Trends Biochem. Sci. 17:72-76(1992). | |
| PubMed ID | 1566332 |
| 2 | Authors | Rose T.M. Bruce A.G. |
| Title | Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 88:8641-8645(1991). | |
| PubMed ID | 1717982 |
| 3 | Authors | Kallestad J.C. Shoyab M. Linsley P.S. |
| Title | Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. | |
| Source | J. Biol. Chem. 266:8940-8945(1991). | |
| PubMed ID | 2026606 |
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