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PROSITE documentation PDOC00227 |
The following cytokines can be grouped into a single family on the basis of sequence similarities.
These cytokines are glycoproteins of about 170 to 180 amino acid residues that contains four conserved cysteine residues involved in two disulfide bonds [4], as shown in the following schematic representation.
+--+ +---+ | | | | xxxxxxxxxxxCxxCxxxxxCxxxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx **********
'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
The pattern developed for this family of proteins includes the last two cysteines as well as other conserved residues.
Note:It has been said [5] that this family can be extended by the adjunction of LIF and OSM (see the relevant entry <PDOC00509>) but, while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of only one single consensus pattern.
Expert(s) to contact by email: Last update:May 2004 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Kishimoto T. Hirano T. |
Title | A new interleukin with pleiotropic activities. | |
Source | BioEssays 9:11-15(1988). | |
PubMed ID | 3063260 |
2 | Authors | Metcalf D. |
Title | The granulocyte-macrophage colony-stimulating factors. | |
Source | Science 229:16-22(1985). | |
PubMed ID | 2990035 |
3 | Authors | Leutz A. Damm K. Sterneck E. Kowenz E. Ness S. Frank R. Gausepohl H. Pan Y.-C.E. Smart J. Hayman M. Graf T. |
Title | Molecular cloning of the chicken myelomonocytic growth factor (cMGF) reveals relationship to interleukin 6 and granulocyte colony stimulating factor. | |
Source | EMBO J. 8:175-181(1989). | |
PubMed ID | 2785450 |
4 | Authors | Clogston C.L. Boone T.C. Crandall B.C. Mendiaz E.A. Lu H.S. |
Title | Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor. | |
Source | Arch. Biochem. Biophys. 272:144-151(1989). | |
PubMed ID | 2472117 |
5 | Authors | Rose T.M. Bruce A.G. |
Title | Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 88:8641-8645(1991). | |
PubMed ID | 1717982 |