PROSITE entry PS00254

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00254
Entry name [info]	INTERLEUKIN_6
Accession [info]	PS00254
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-1990 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00227

Name and characterization of the entry

Description [info]	Interleukin-6 / G-CSF / MGF signature.
Pattern [info]	C-x(9)-C-x(6)-G-L-x(2)-[FY]-x(3)-L.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	39 in 39 different sequences
Number of true positive hits	37 in 37 different sequences
Number of 'unknown' hits	0
Number of false positive hits	2 in 2 different sequences
Number of false negative sequences	3
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	94.87 %
Recall (true positives / (true positives + false negatives))	92.50 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Site [info]	disulfide at position 1
Site [info]	disulfide at position 3
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	37 sequences CSF3_BOVIN (P35833), CSF3_CANLF (P35834), CSF3_FELCA (O02708), CSF3_HUMAN (P09919), CSF3_MOUSE (P09920), CSF3_PIG(O02837), CSF3_SHEEP (Q28746), IL6_BOVIN (P26892), IL6_BUBBU (Q6V919), IL6_BUBCA (Q2MH06), IL6_CAMBA (Q865W7), IL6_CANLF (P41323), IL6_CAPHI (Q28319), IL6_CERAT (P46650), IL6_CHICK (Q90YI0), IL6_DELLE (Q9XT80), IL6_FELCA (P41683), IL6_HORSE (Q95181), IL6_HUMAN (P05231), IL6_LAMGL (Q865X6), IL6_MACFA (P79341), IL6_MACMU (P51494), IL6_MACTH (Q5I6E3), IL6_MARMO (O35736), IL6_MOUSE (P08505), IL6_MUSPF (A3FBE9), IL6_NEOVI (P41693), IL6_ORCOR (Q28747), IL6_PHOVI (Q28819), IL6_PIG (P26893), IL6_RABIT (Q9MZR1), IL6_RAT (P20607), IL6_SAISC (Q8MKH0), IL6_SHEEP (P29455), IL6_TAKRU (Q6L6X6), IL6_VULVU (Q25BC2), MGF_CHICK (P13854) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	3 sequences IL6_ONCMY (Q0GGL7), IL6_PAROL (A0S0B0), IL6_SPAAU (B6CKP4)
UniProtKB/Swiss-Prot False positive sequences	2 sequences CSOCA_HALNC (O85042), SDEA_EMENI (C8V7U7)
PDB [Detailed view]	28 PDB 1ALU; 1BGC; 1BGD; 1BGE; 1CD9; 1GNC; 1IL6; 1P9M; 1PGR; 1RHG; 2D9Q; 2IL6; 2L3Y; 4CNI; 4J4L; 4NI7; 4NI9; 4O9H; 4ZS7; 5FUC; 5GW9; 5ZO6; 7NXZ; 8D82; 8QY5; 8QY6; 8YWQ; 8YWR » more