PROSITE entry PS00254

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

Entry name [info]	INTERLEUKIN_6
Accession [info]	PS00254
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-1990 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00227

Name and characterization of the entry

Description [info]	Interleukin-6 / G-CSF / MGF signature.
Pattern [info]	C-x(9)-C-x(6)-G-L-x(2)-[FY]-x(3)-L.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	39 in 39 different sequences
Number of true positive hits	37 in 37 different sequences
Number of 'unknown' hits	0
Number of false positive hits	2 in 2 different sequences
Number of false negative sequences	3
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	94.87 %
Recall (true positives / (true positives + false negatives))	92.50 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Site [info]	disulfide at position 1
Site [info]	disulfide at position 3
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	37 sequences CSF3_BOVIN (P35833), CSF3_CANLF (P35834), CSF3_FELCA (O02708), CSF3_HUMAN (P09919), CSF3_MOUSE (P09920), CSF3_PIG(O02837), CSF3_SHEEP (Q28746), IL6_BOVIN (P26892), IL6_BUBBU (Q6V919), IL6_BUBCA (Q2MH06), IL6_CAMBA (Q865W7), IL6_CANLF (P41323), IL6_CAPHI (Q28319), IL6_CERAT (P46650), IL6_CHICK (Q90YI0), IL6_DELLE (Q9XT80), IL6_FELCA (P41683), IL6_HORSE (Q95181), IL6_HUMAN (P05231), IL6_LAMGL (Q865X6), IL6_MACFA (P79341), IL6_MACMU (P51494), IL6_MACTH (Q5I6E3), IL6_MARMO (O35736), IL6_MOUSE (P08505), IL6_MUSPF (A3FBE9), IL6_NEOVI (P41693), IL6_ORCOR (Q28747), IL6_PHOVI (Q28819), IL6_PIG (P26893), IL6_RABIT (Q9MZR1), IL6_RAT (P20607), IL6_SAISC (Q8MKH0), IL6_SHEEP (P29455), IL6_TAKRU (Q6L6X6), IL6_VULVU (Q25BC2), MGF_CHICK (P13854) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	3 sequences IL6_ONCMY (Q0GGL7), IL6_PAROL (A0S0B0), IL6_SPAAU (B6CKP4)
UniProtKB/Swiss-Prot False positive sequences	2 sequences CSOCA_HALNC (O85042), SDEA_EMENI (C8V7U7)
PDB [Detailed view]	24 PDB 1ALU; 1BGC; 1BGD; 1BGE; 1CD9; 1GNC; 1IL6; 1P9M; 1PGR; 1RHG; 2D9Q; 2IL6; 2L3Y; 4CNI; 4J4L; 4NI7; 4NI9; 4O9H; 4ZS7; 5FUC; 5GW9; 5ZO6; 7NXZ; 8D82 » more