PROSITE documentation PDOC00539
recF protein signatures


The prokaryotic protein recF [1,2] is a single-stranded DNA-binding protein which also probably binds ATP. RecF is involved in DNA metabolism; it is required for recombinational DNA repair and for induction of the SOS response.

RecF is a protein of about 350 to 370 amino acid residues; there is a conserved ATP-binding site motif 'A' (P-loop) in the N-terminal section of the protein as well as two other conserved regions, one located in the central section, and the other in the C-terminal section. We have derived signature patterns from these two regions.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

RECF_1, PS00617; RecF protein signature 1  (PATTERN)

RECF_2, PS00618; RecF protein signature 2  (PATTERN)


1AuthorsSandler S.J. Chackerian B. Li J.T. Clark A.J.
TitleSequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop.
SourceNucleic Acids Res. 20:839-845(1992).
PubMed ID1542576

2AuthorsAlonso J.C. Fisher L.M.
TitleNucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants.
SourceMol. Gen. Genet. 246:680-686(1995).
PubMed ID7898435

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