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PROSITE documentation PDOC00541

Tissue factor signature





Description

Tissue factor (TF) [1,2] is an integral membrane glycoprotein that initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The complex then activates factors IX or X by specific limited proteolysis.

The mature form of TF is a protein of about 250 amino acid residues. TF consists of an extracellular domain of about 210 residues that contains two disulfide bonds, followed by a transmembrane region and a short cytoplasmic C-terminal domain. This structure is shown in the following schematic representation:

   +----------*****---------------------------------------xxxxx----+
   |           C C       Extracellular            C    C  XXXXX Cyt|
   +-----------|-|--------------------------------|----|--xxxxx----+
               | |                                |    |  Transm.
               +-+                                +----+
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

As a pattern for TF, we have used the region centered on the two cysteines involved in the first disulfide bond.

Last update:

May 2004 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

TISSUE_FACTOR, PS00621; Tissue factor signature  (PATTERN)


References

1AuthorsBach R.R.
TitleInitiation of coagulation by tissue factor.
SourceCRC Crit. Rev. Biochem. 23:339-368(1988).
PubMed ID3067973

2AuthorsBarcham G.J. Andrews A.E. Nash A.D.
TitleCloning and expression of a cDNA encoding ovine interleukin 7.
SourceGene 154:265-269(1995).
PubMed ID7890175



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