PROSITE documentation PDOC00541Tissue factor signature
Tissue factor (TF) [1,2] is an integral membrane glycoprotein that initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The complex then activates factors IX or X by specific limited proteolysis.
The mature form of TF is a protein of about 250 amino acid residues. TF consists of an extracellular domain of about 210 residues that contains two disulfide bonds, followed by a transmembrane region and a short cytoplasmic C-terminal domain. This structure is shown in the following schematic representation:
+----------*****---------------------------------------xxxxx----+
| C C Extracellular C C XXXXX Cyt|
+-----------|-|--------------------------------|----|--xxxxx----+
| | | | Transm.
+-+ +----+
'C': conserved cysteine involved in a disulfide bond. '*': position of the pattern.
As a pattern for TF, we have used the region centered on the two cysteines involved in the first disulfide bond.
Last update:May 2004 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bach R.R. |
| Title | Initiation of coagulation by tissue factor. | |
| Source | CRC Crit. Rev. Biochem. 23:339-368(1988). | |
| PubMed ID | 3067973 |
| 2 | Authors | Barcham G.J. Andrews A.E. Nash A.D. |
| Title | Cloning and expression of a cDNA encoding ovine interleukin 7. | |
| Source | Gene 154:265-269(1995). | |
| PubMed ID | 7890175 |
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