We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00545GHMP kinases putative ATP-binding domain
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00545
Description
The following kinases contains, in their N-terminal section, a conserved Gly/ Ser-rich region which is probably involved in the binding of ATP [1]. These kinases are listed below.
- Galactokinase (EC 2.7.1.6).
- Homoserine kinase (EC 2.7.1.39).
- Mevalonate kinase (EC 2.7.1.36).
- Phosphomevalonate kinase (EC 2.7.4.2).
We have called this group of kinases 'GHMP' (from the first letter of their substrate).
Last update:December 2001 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Tsay Y.H. Robinson G.W. |
| Title | Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. | |
| Source | Mol. Cell. Biol. 11:620-631(1991). | |
| PubMed ID | 1846667 |
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