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	PROSITE documentation PDOC00545

GHMP kinases putative ATP-binding domain

The following kinases contains, in their N-terminal section, a conserved Gly/ Ser-rich region which is probably involved in the binding of ATP [1]. These kinases are listed below.

• Galactokinase (EC 2.7.1.6).
• Homoserine kinase (EC 2.7.1.39).
• Mevalonate kinase (EC 2.7.1.36).
• Phosphomevalonate kinase (EC 2.7.4.2).

We have called this group of kinases 'GHMP' (from the first letter of their substrate).

Last update:

December 2001 / Pattern and text revised.

PROSITE method (with tools and information) covered by this documentation:

GHMP_KINASES_ATP, PS00627; GHMP kinases putative ATP-binding domain  (PATTERN)

• Consensus pattern:
  [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-[LM]-[GS]-S-S-[GSA]-[GSTAC]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 545
  • detected by PS00627: 483 (true positives)
  • undetected by PS00627: 62 (62 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00627:
  3 false positives.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00627
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00627
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00627
• View ligand binding statistics of PS00627
• Matching PDB structures: 1FWK 1FWL 1H72 1H73 ... [ALL]

1	Authors	Tsay Y.H. Robinson G.W.
	Title	Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.
	Source	Mol. Cell. Biol. 11:620-631(1991).
	PubMed ID	1846667

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