A number of bacterial proteins, some of which are involved in a general
secretion pathway (GSP) for the export of proteins (also called the type II
pathway) [1,2], have been found to be evolutionary related. These proteins
are listed below:
The 'E' protein from the GSP operon of: Aeromonas (gene exeE); Erwinia
(gene outE); Escherichia coli (gene yheG); Klebsiella pneumoniae (gene
pulE); Pseudomonas aeruginosa (gene xcpR); Vibrio cholerae (gene epsE) and
Xanthomonas campestris (gene xpsE).
Agrobacterium tumefaciens Ti plasmid virB operon protein 11. This protein
is required for the transfer of T-DNA to plants.
Bacillus subtilis comG operon protein 1 which is required for the uptake of
DNA by competent Bacillus subtilis cells.
Aeromonas hydrophila tapB, involved in type IV pilus assembly.
Pseudomonas protein pilB, which is essential for the formation of the pili.
Pseudomonas aeruginosa protein twitching mobility protein pilT.
Neisseria gonorrhoeae type IV pilus assembly protein pilF.
Vibrio cholerae protein tcpT, which is involved in the biosynthesis of the
Escherichia coli protein hofB (hopB).
Escherichia coli hypothetical protein ygcB.
Escherichia coli hypothetical protein yggR.
These proteins have from 344 (pilT and virB11) to 568 (tapB) amino acids, they
are probably cytoplasmically located and, on the basis of the presence of a
conserved P-loop region (see <PDOC00017>), probably bind ATP. As a signature
pattern we selected a region that overlaps the 'B' motif of ATP-binding
Common components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes.
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