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PROSITE documentation PDOC00573

D-amino acid oxidases signature





Description

D-amino acid oxidase (EC 1.4.3.3) (DAMOX or DAO) is an FAD flavoenzyme that catalyzes the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterized and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes.

D-aspartate oxidase (EC 1.4.3.1) (DASOX) [1] is an enzyme, structurally related to DAO, which catalyzes the same reaction but is active only toward dicarboxylic D-amino acids.

In DAO, a conserved histidine has been shown [2] to be important for the enzyme's catalytic activity. We have used the conserved region around this residue as a signature pattern for these enzymes.

Last update:

May 2004 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DAO, PS00677; D-amino acid oxidases signature  (PATTERN)


References

1AuthorsNegri A. Ceciliani F. Tedeschi G. Simonic T. Ronchi S.
TitleThe primary structure of the flavoprotein D-aspartate oxidase from beef kidney.
SourceJ. Biol. Chem. 267:11865-11871(1992).
PubMed ID1601857

2AuthorsMiyano M. Fukui K. Watanabe F. Takahashi S. Tada M. Kanashiro M. Miyake Y.
TitleStudies on Phe-228 and Leu-307 recombinant mutants of porcine kidney D-amino acid oxidase: expression, purification, and characterization.
SourceJ. Biochem. 109:171-177(1991).
PubMed ID1673125



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