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PROSITE documentation PDOC00609F-actin capping protein alpha subunit signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00609
The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: α and β.
The α subunit is a protein of about 268 to 308 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As signature patterns we selected two highly conserved regions in the C-terminal section of the α subunit.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Cooper J.A. Caldwell J.E. Gattermeir D.J. Torres M.A. Amatruda J.F. Casella J.F. |
| Title | Variant cDNAs encoding proteins similar to the alpha subunit o chicken CapZ. | |
| Source | Cell Motil. Cytoskeleton 18:204-214(1991). | |
| PubMed ID | 1711931 |
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