PROSITE documentation PDOC00632Involucrin signature
Involucrin [1,2] is a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane.
Structurally involucrin consists of a conserved region of about 75 amino acid residues followed by two extremely variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The total size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).
The signature pattern for involucrin corresponds to the N-terminal extremity of the protein.
Last update:November 1997 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Green H. Djian P. |
| Title | Consecutive actions of different gene-altering mechanisms in the evolution of involucrin. | |
| Source | Mol. Biol. Evol. 9:977-1017(1992). | |
| PubMed ID | 1359382 |
| 2 | Authors | Djian P. Phillips M. Easley K. Huang E. Simon M. Rice R.H. Green H. |
| Title | The involucrin genes of the mouse and the rat: study of their shared repeats. | |
| Source | Mol. Biol. Evol. 10:1136-1149(1993). | |
| PubMed ID | 8277848 |
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