PROSITE documentation PDOC00632
Involucrin signature


Involucrin [1,2] is a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane.

Structurally involucrin consists of a conserved region of about 75 amino acid residues followed by two extremely variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The total size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).

The signature pattern for involucrin corresponds to the N-terminal extremity of the protein.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

INVOLUCRIN, PS00795; Involucrin signature  (PATTERN)


1AuthorsGreen H. Djian P.
TitleConsecutive actions of different gene-altering mechanisms in the evolution of involucrin.
SourceMol. Biol. Evol. 9:977-1017(1992).
PubMed ID1359382

2AuthorsDjian P. Phillips M. Easley K. Huang E. Simon M. Rice R.H. Green H.
TitleThe involucrin genes of the mouse and the rat: study of their shared repeats.
SourceMol. Biol. Evol. 10:1136-1149(1993).
PubMed ID8277848

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