We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00634Granulins signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00634
Description
Granulins [1] are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. A schematic representation of the structure of a granulin is shown below:
xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx
**************
'C': conserved cysteine probably involved in a disulfide bond. '*': position of the pattern.
Granulins are evolutionary related to a PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts [2].
Last update:May 2004 / Text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Bhandari V. Palfree R.G. Bateman A. |
| Title | Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992). | |
| PubMed ID | 1542665 |
| 2 | Authors | Nakakura N. Hietter H. Van Dorsselaer A. Luu B. |
| Title | Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide. | |
| Source | Eur. J. Biochem. 204:147-153(1992). | |
| PubMed ID | 1740125 |
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