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PROSITE documentation PDOC00634

Granulins signature





Description

Granulins [1] are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. A schematic representation of the structure of a granulin is shown below:

       xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx
                                         **************
'C': conserved cysteine probably involved in a disulfide bond.
'*': position of the pattern.

Granulins are evolutionary related to a PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts [2].

Last update:

May 2004 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GRANULINS, PS00799; Granulins signature  (PATTERN)


References

1AuthorsBhandari V. Palfree R.G. Bateman A.
TitleIsolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
SourceProc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
PubMed ID1542665

2AuthorsNakakura N. Hietter H. Van Dorsselaer A. Luu B.
TitleIsolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide.
SourceEur. J. Biochem. 204:147-153(1992).
PubMed ID1740125



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