PROSITE documentation PDOC00634Granulins signature
Description
Granulins [1] are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. A schematic representation of the structure of a granulin is shown below:
xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx
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'C': conserved cysteine probably involved in a disulfide bond. '*': position of the pattern.
Granulins are evolutionary related to a PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts [2].
Last update:May 2004 / Text revised.
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Technical section
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References
| 1 | Authors | Bhandari V. Palfree R.G. Bateman A. |
| Title | Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992). | |
| PubMed ID | 1542665 |
| 2 | Authors | Nakakura N. Hietter H. Van Dorsselaer A. Luu B. |
| Title | Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide. | |
| Source | Eur. J. Biochem. 204:147-153(1992). | |
| PubMed ID | 1740125 |
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