Escherichia coli protease VII (EC 22.214.171.124) (omptin) (gene ompT)  is an
outer-membrane associated protease with a specificity for paired basic
residues. It seems to be an aspartyl protease  inhibited by zinc ions.
Omptin is highly similar to the following proteins:
Salmonella typhimurium outer membrane protease E (gene pgtE) , also
specific for paired basic residues.
Yersinia pestis coagulase/fibrinolysin (plasminogen activator) (gene pla)
. This enzyme is encoded on a plasmid required for the pathogenic
potential of the bacteria. It cleaves and activates plasminogen at the foci
of infection; this allows plasmin to degrade fibrin barriers thus promoting
the invasiveness of the plague bacteria.
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