Some oxygen-dependent oxidoreductases are flavoproteins that contains a
covalently bound FAD group which is attached to a histidine via an 8-α-(N3-histidyl)-riboflavin linkage. These proteins are:
(R)-6-hydroxynicotine oxidase (EC 220.127.116.11) (6-HDNO) , a bacterial enzyme
that catalyzes the oxygen-dependent degradation of 6-hydroxynicotine into
Plant reticuline oxidase (EC 18.104.22.168)  (berberine-bridge-forming
enzyme), an enzyme that catalyzes the oxidation of (S)-reticuline into (S)-
scoulerine in the pathway leading to benzophenanthridine alkaloids.
L-gulonolactone oxidase (EC 22.214.171.124) (l-gulono-γ-lactone oxidase) ,
a mammalian enzyme which catalyzes the oxidation of L-gulono-1,4-lactone to
L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.
D-arabinono-1,4-lactone oxidase (EC 126.96.36.199) (L-galactonolactone oxidase),
a yeast enzyme involved in the biosynthesis of D-erythroascorbic acid .
Mitomycin radical oxidase , a bacterial protein involved in mitomycin
resistance and that probably oxidizes the reduced form of mitomycins.
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