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PROSITE documentation PDOC00675Calsequestrin signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00675
Calsequestrin is a moderate-affinity, high-capacity calcium-binding protein of cardiac and skeletal muscle [1], where it is located in the lumenal space of the sarcoplasmic reticulum terminal cisternae. Calsequestrin acts as a calcium buffer and plays an important role in the muscle excitation-contraction coupling. It is a highly acidic protein of about 400 amino acid residues that binds more than 40 moles of calcium per mole of protein. There are at least two different forms of calsequestrin: one which is expressed in cardiac muscles and another in skeletal muscles. Both forms have highly similar sequences.
We have developed two signature sequences, the first one corresponds to the N-terminus of the mature protein; the second is located just in front of the C-terminus of the protein which is composed of a highly acidic tail of variable length.
Last update:October 1993 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Treves S. Vilsen B. Chiozzi P. Andersen J.P. Zorzato F. |
| Title | Molecular cloning, functional expression and tissue distribution of the cDNA encoding frog skeletal muscle calsequestrin. | |
| Source | Biochem. J. 283:767-772(1992). | |
| PubMed ID | 1375450 |
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