PROSITE documentation PDOC00675
Calsequestrin signatures


Calsequestrin is a moderate-affinity, high-capacity calcium-binding protein of cardiac and skeletal muscle [1], where it is located in the lumenal space of the sarcoplasmic reticulum terminal cisternae. Calsequestrin acts as a calcium buffer and plays an important role in the muscle excitation-contraction coupling. It is a highly acidic protein of about 400 amino acid residues that binds more than 40 moles of calcium per mole of protein. There are at least two different forms of calsequestrin: one which is expressed in cardiac muscles and another in skeletal muscles. Both forms have highly similar sequences.

We have developed two signature sequences, the first one corresponds to the N-terminus of the mature protein; the second is located just in front of the C-terminus of the protein which is composed of a highly acidic tail of variable length.

Last update:

October 1993 / First entry.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

CALSEQUESTRIN_1, PS00863; Calsequestrin signature 1  (PATTERN)

CALSEQUESTRIN_2, PS00864; Calsequestrin signature 2  (PATTERN)


1AuthorsTreves S. Vilsen B. Chiozzi P. Andersen J.P. Zorzato F.
TitleMolecular cloning, functional expression and tissue distribution of the cDNA encoding frog skeletal muscle calsequestrin.
SourceBiochem. J. 283:767-772(1992).
PubMed ID1375450

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