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PROSITE documentation PDOC00683

Bacterial type II secretion system protein D signature





Description

A number of bacterial proteins, some of which are involved in a general secretion pathway (GSP) for the export of proteins (also called the type II pathway) [1,2,3,4,5], have been found to be evolutionary related. These proteins are listed below:

  • The 'D' protein from the GSP operon of: Aeromonas (gene exeD); Erwinia (gene outD); Escherichia coli (gene yheF), Klebsiella pneumoniae (gene pulD); Pseudomonas aeruginosa (gene xcpQ); Vibrio cholerae (gene epsD) and Xanthomonas campestris (gene xpsD).
  • comE from Haemophilus influenzae, involved in competence (DNA uptake).
  • pilQ from Pseudomonas aeruginosa, which is essential for the formation of the pili.
  • hofQ (hopQ) from Escherichia coli.
  • hrpH from Pseudomonas syringae, which is involved in the secretion of a proteinaceous elicitor of the hypersensitivity response in plants.
  • hrpA1 from Xanthomonas campestris pv. vesicatoria, which is also involved in the hypersensitivity response.
  • mxiD from Shigella flexneri which is involved in the secretion of the Ipa invasins which are necessary for penetration of intestinal epithelial cells.
  • omc from Neisseria gonorrhoeae.
  • yssC from Yersinia enterocolitica virulence plasmid pYV, which seems to be required for the export of the Yop virulence proteins.
  • The gpIV protein from filamentous phages such as f1, ike, or m13. GpIV is said to be involved in phage assembly and morphogenesis.

These proteins all seem to start with a signal sequence and are thought to be integral proteins in the outer membrane. As a signature pattern we selected a conserved region in the C-terminal section of these proteins.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

T2SP_D, PS00875; Bacterial type II secretion system protein D signature  (PATTERN)


References

1AuthorsSalmond G.P.C. Reeves P.J.
TitleMembrane traffic wardens and protein secretion in gram-negative bacteria.
SourceTrends Biochem. Sci. 18:7-12(1993).
PubMed ID8438237

2AuthorsReeves P.J. Whitcombe D. Wharam S. Gibson M. Allison G. Bunce N. Barallon R. Douglas P. Mulholland V. Stevens S. Walker S. Salmond G.P.C.
TitleMolecular cloning and characterization of 13 out genes from Erwinia carotovora subspecies carotovora: genes encoding members of a general secretion pathway (GSP) widespread in gram-negative bacteria.
SourceMol. Microbiol. 8:443-456(1993).
PubMed ID8326859

3AuthorsMartin P.R. Hobbs M. Free P.D. Jeske Y. Mattick J.S.
TitleCharacterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa.
SourceMol. Microbiol. 9:857-868(1993).
PubMed ID7901733

4AuthorsHobbs M. Mattick J.S.
TitleCommon components in the assembly of type 4 fimbriae, DNA transfer systems, filamentous phage and protein-secretion apparatus: a general system for the formation of surface-associated protein complexes.
SourceMol. Microbiol. 10:233-243(1993).
PubMed ID7934814

5AuthorsGenin S. Boucher C.A.
TitleA superfamily of proteins involved in different secretion pathways in gram-negative bacteria: modular structure and specificity of the N-terminal domain.
SourceMol. Gen. Genet. 243:112-118(1994).
PubMed ID8190064



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