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PROSITE documentation PDOC00708

Dihydroorotate dehydrogenase signatures





Description

Dihydroorotate dehydrogenase (EC 1.3.3.1) (DHOdehase) catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein.

In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [1].

The sequence of DHOdease is rather well conserved and we have developed two signature patterns specific to this enzyme. The first corresponds to a region in the N-terminal section of the enzyme while the second is located in the C-terminal section and seems to be part of the FAD-binding domain.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

DHODEHASE_1, PS00911; Dihydroorotate dehydrogenase signature 1  (PATTERN)

DHODEHASE_2, PS00912; Dihydroorotate dehydrogenase signature 2  (PATTERN)


Reference

1AuthorsNagy M. Lacroute F. Thomas D.
TitleDivergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.
SourceProc. Natl. Acad. Sci. U.S.A. 89:8966-8970(1992).
PubMed ID1409592



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