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PROSITE documentation PDOC00708Dihydroorotate dehydrogenase signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00708
Dihydroorotate dehydrogenase (EC 1.3.3.1) (DHOdehase) catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein.
In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [1].
The sequence of DHOdease is rather well conserved and we have developed two signature patterns specific to this enzyme. The first corresponds to a region in the N-terminal section of the enzyme while the second is located in the C-terminal section and seems to be part of the FAD-binding domain.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Nagy M. Lacroute F. Thomas D. |
| Title | Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:8966-8970(1992). | |
| PubMed ID | 1409592 |
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