PROSITE documentation PDOC00724
Ribosomal protein L1e signature


A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists [1,2,3,4] of:

  • Vertebrate L1 (L4).
  • Drosophila L1.
  • Plant L1.
  • Yeast L2 (Rp2).
  • Fission yeast L2.
  • Halobacterium marismortui HmaL4 (HL6).
  • Methanococcus jannaschii MJ0177.

These proteins have 246 (archaebacteria) to 427 (human) amino acids. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L1E, PS00939; Ribosomal protein L1e signature  (PATTERN)


1AuthorsRafti F. Gargiulo G. Manzi A. Malva C. Graziani F.
TitleSequence of the ribosomal protein cDNA of D. melanogaster homologous to the L1 ribosomal protein gene of X. laevis.
SourceNucleic Acids Res. 17:456-456(1989).
PubMed ID2492096

2AuthorsPresutti C. Villa T. Bozzoni I.
TitleThe primary sequence of the Schizosaccharomyces pombe protein homologous to S.cerevisiae ribosomal protein L2.
SourceNucleic Acids Res. 21:3900-3900(1993).
PubMed ID8367312

3AuthorsBagni C. Mariottini P. Annesi F. Amaldi F.
TitleHuman ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein.
SourceBiochim. Biophys. Acta 1216:475-478(1993).
PubMed ID8268230

4AuthorsArndt E. Kroemer W. Hatakeyama T.
TitleOrganization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui.
SourceJ. Biol. Chem. 265:3034-3039(1990).
PubMed ID2406244

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