We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00724Ribosomal protein L1e signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00724
Description
A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. One of these families consists [1,2,3,4] of:
- Vertebrate L1 (L4).
- Drosophila L1.
- Plant L1.
- Yeast L2 (Rp2).
- Fission yeast L2.
- Halobacterium marismortui HmaL4 (HL6).
- Methanococcus jannaschii MJ0177.
These proteins have 246 (archaebacteria) to 427 (human) amino acids. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Rafti F. Gargiulo G. Manzi A. Malva C. Graziani F. |
| Title | Sequence of the ribosomal protein cDNA of D. melanogaster homologous to the L1 ribosomal protein gene of X. laevis. | |
| Source | Nucleic Acids Res. 17:456-456(1989). | |
| PubMed ID | 2492096 |
| 2 | Authors | Presutti C. Villa T. Bozzoni I. |
| Title | The primary sequence of the Schizosaccharomyces pombe protein homologous to S.cerevisiae ribosomal protein L2. | |
| Source | Nucleic Acids Res. 21:3900-3900(1993). | |
| PubMed ID | 8367312 |
| 3 | Authors | Bagni C. Mariottini P. Annesi F. Amaldi F. |
| Title | Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. | |
| Source | Biochim. Biophys. Acta 1216:475-478(1993). | |
| PubMed ID | 8268230 |
| 4 | Authors | Arndt E. Kroemer W. Hatakeyama T. |
| Title | Organization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui. | |
| Source | J. Biol. Chem. 265:3034-3039(1990). | |
| PubMed ID | 2406244 |
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