PROSITE documentation PDOC00742
BTG family signatures


A novel family of anti-proliferative proteins has been recently [1,2] characterized:

  • Mammalian and avian protein BTG1. BTG1 seems to negatively regulate cell proliferation.
  • Mammalian protein BTG2 (also known as PC3 or TIS21).
  • Mammalian protein BTG3 (also known as TOB5).
  • Mammalian protein BTG4 (also known as PC3b).
  • Mammalian protein TOB, an anti-proliferative protein that interacts with the erbb-2 receptor tyrosine kinase [3].
  • Human protein TOB4.
  • Xenopus laevis maternal proteins B9.10 and B9.15 (which are probably the orthologs of BTG3).

The proteins have from 158 to 363 amino acid residues. BTG2 seems to have a signal sequence; while the other proteins may lack such a domain. The sequence of the N-terminal half of these proteins is well conserved. As signature patterns, we selected the two best conserved regions of these proteins. The first signature pattern includes the only conserved cysteine.

Expert(s) to contact by email:

Duret L.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

BTG_1, PS00960; BTG family signature 1  (PATTERN)

BTG_2, PS01203; BTG family signature 2  (PATTERN)


1AuthorsRouault J.-P. Rimokh R. Tessa C. Paranhos G. Ffrench M. Duret L. Garoccio M. Germain D. Samarut J. Magaud J.-P.
TitleBTG1, a member of a new family of antiproliferative genes.
SourceEMBO J. 11:1663-1670(1992).
PubMed ID1373383

2AuthorsRouault J.-P. Samarut C. Duret L. Tessa C. Samarut J. Magaud J.-P.
TitleSequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions.
SourceGene 129:303-306(1993).
PubMed ID8325512

3AuthorsMatsuda S. Kawamura-Tsuzuku J. Ohsugi M. Yoshida M. Emi M. Nakamura Y. Onda M. Yoshida Y. Nishiyama A. Yamamoto T.
TitleTob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.
SourceOncogene 12:705-713(1996).
PubMed ID8632892

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