We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00752Myristoyl-CoA:protein N-myristoyltransferase signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00752
Description
Myristoyl-CoA:protein N-myristoyltransferase (EC 2.3.1.97) (Nmt) [1] is the enzyme responsible for transferring a myristate group on the N-terminal glycine of a number of cellular eukaryotics and viral proteins.
Nmt is a monomeric protein of about 50 to 60 Kd whose sequence appears to be well conserved. We used two highly conserved regions as signature patterns. The first one is located in the central section, the second in the C-terminal part.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE methods (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Rudnick D.A. McWherter C.A. Gokel G.W. Gordon J.I. |
| Title | MyristoylCoA:protein N-myristoyltransferase. | |
| Source | Adv. Enzymol. Relat. Areas Mol. Biol. 67:375-430(1993). | |
| PubMed ID | 8322618 |
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