PROSITE documentation PDOC00757
Urotensin II signature


Urotensin II [1,2] is a small peptide originally isolated from the caudal portion of the spinal cord of teleost and elasmobranch fish but which has also been found in the brain of frogs. Urotensin II seems to be involved in smooth muscle stimulation. It is a peptide of 12 to 13 residues that contains a disulfide bridge.

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'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.
Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UROTENSIN_II, PS00984; Urotensin II signature  (PATTERN)


1AuthorsConlon J.M. O'Harte F. Smith D.D. Tonon M.-C. Vaudry H.
TitleIsolation and primary structure of urotensin II from the brain of a tetrapod, the frog Rana ridibunda.
SourceBiochem. Biophys. Res. Commun. 188:578-583(1992).
PubMed ID1445302

2AuthorsConlon J.M. O'Harte F. Smith D.D. Balment R.J. Hazon N.
TitlePurification and characterization of urotensin II and parvalbumin from an elasmobranch fish, Scyliorhinus canicula (common dogfish).
SourceNeuroendocrinology 55:230-235(1992).
PubMed ID1620290

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