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PROSITE documentation PDOC00766

Streptomyces subtilisin-type inhibitors signature





Description

Bacteria of the Streptomyces family produce a family of proteinase inhibitors [1] characterized by their strong activity toward subtilisin. They are collectively known as SSI's: Streptomyces Subtilisin Inhibitors. Some SSI's also inhibit trypsin or chymotrypsin. In their mature secreted form, SSI's are proteins of about 110 residues with two conserved disulfide bonds.

                       +-------+         +--------------+
                       |       |         |              |
         xxxxxxxxxxxxxxCxxxxxxxCxxxxxxxxxCx#xxxxxxxxxxxxCxxxxxx
                       ************
'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.
Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SSI, PS00999; Streptomyces subtilisin-type inhibitors signature  (PATTERN)


Reference

1AuthorsTaguchi S. Kojima S. Terabe M. Miura K.-I. Momose H.
TitleComparative studies on the primary structures and inhibitory properties of subtilisin-trypsin inhibitors from Streptomyces.
SourceEur. J. Biochem. 220:911-918(1994).
PubMed ID8143745



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