PROSITE documentation PDOC00766Streptomyces subtilisin-type inhibitors signature
Description
Bacteria of the Streptomyces family produce a family of proteinase inhibitors [1] characterized by their strong activity toward subtilisin. They are collectively known as SSI's: Streptomyces Subtilisin Inhibitors. Some SSI's also inhibit trypsin or chymotrypsin. In their mature secreted form, SSI's are proteins of about 110 residues with two conserved disulfide bonds.
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xxxxxxxxxxxxxxCxxxxxxxCxxxxxxxxxCx#xxxxxxxxxxxxCxxxxxx
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'C': conserved cysteine involved in a disulfide bond. '#': active site residue. '*': position of the pattern.Last update:
April 2006 / Pattern revised.
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Technical section
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Reference
| 1 | Authors | Taguchi S. Kojima S. Terabe M. Miura K.-I. Momose H. |
| Title | Comparative studies on the primary structures and inhibitory properties of subtilisin-trypsin inhibitors from Streptomyces. | |
| Source | Eur. J. Biochem. 220:911-918(1994). | |
| PubMed ID | 8143745 |
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