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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC00766
Streptomyces subtilisin-type inhibitors signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00766

Description

Bacteria of the Streptomyces family produce a family of proteinase inhibitors [1] characterized by their strong activity toward subtilisin. They are collectively known as SSI's: Streptomyces Subtilisin Inhibitors. Some SSI's also inhibit trypsin or chymotrypsin. In their mature secreted form, SSI's are proteins of about 110 residues with two conserved disulfide bonds. 

                       +-------+         +--------------+
                       |       |         |              |
         xxxxxxxxxxxxxxCxxxxxxxCxxxxxxxxxCx#xxxxxxxxxxxxCxxxxxx
                       ************

'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.
Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SSI, PS00999; Streptomyces subtilisin-type inhibitors signature  (PATTERN)


Reference

1AuthorsTaguchi S. Kojima S. Terabe M. Miura K.-I. Momose H.
TitleComparative studies on the primary structures and inhibitory properties of subtilisin-trypsin inhibitors from Streptomyces.
SourceEur. J. Biochem. 220:911-918(1994).
PubMed ID8143745



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