PROSITE documentation PDOC00771
DnaA protein signature


The bacterial dnaA protein [1,2,3] plays an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).

DnaA is a protein of about 50 Kd that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. We used the most conserved part of the putative DNA-binding domain as a signature pattern.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

DNAA, PS01008; DnaA protein signature  (PATTERN)


1AuthorsSkarstad K. Boye E.
TitleThe initiator protein DnaA: evolution, properties and function.
SourceBiochim. Biophys. Acta 1217:111-130(1994).
PubMed ID8110826

2AuthorsYoshikawa H. Ogasawara N.
TitleStructure and function of DnaA and the DnaA-box in eubacteria: evolutionary relationships of bacterial replication origins.
SourceMol. Microbiol. 5:2589-2597(1991).
PubMed ID1779750

3AuthorsGeorgopoulos C.
TitleThe E. coli dnaA initiation protein: a protein for all seasons.
SourceTrends Genet. 5:319-321(1989).
PubMed ID2558436

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