Folylpolyglutamate synthase (EC 184.108.40.206) (FPGS)  is the enzyme of folate
metabolism that catalyzes ATP-dependent addition of glutamate moieties to
Its sequence is moderately conserved between prokaryotes (gene folC) and
eukaryotes. We developed two signature patterns based on the conserved regions
which are rich in glycine residues and could play a role in the catalytical
activity and/or in substrate binding.
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