PROSITE documentation PDOC00773Folylpolyglutamate synthase signatures
Description
Folylpolyglutamate synthase (EC 6.3.2.17) (FPGS) [1] is the enzyme of folate metabolism that catalyzes ATP-dependent addition of glutamate moieties to tetrahydrofolate.
Its sequence is moderately conserved between prokaryotes (gene folC) and eukaryotes. We developed two signature patterns based on the conserved regions which are rich in glycine residues and could play a role in the catalytical activity and/or in substrate binding.
Last update:December 2004 / Patterns and text revised.
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Technical section
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Reference
| 1 | Authors | Shane B. Garrow T. Brenner A. Chen L. Choi Y.J. Hsu J.C. Stover P. |
| Title | Folylpoly-gamma-glutamate synthetase. | |
| Source | Adv. Exp. Med. Biol. 338:629-634(1993). | |
| PubMed ID | 8304196 |
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