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PROSITE documentation PDOC00788Dehydroquinase class I active site
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00788
3-dehydroquinate dehydratase (EC 4.2.1.10), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. The best studied type I enzyme is from Escherichia coli (gene aroD) and related bacteria where it is a homodimeric protein of a chain of about 250 residues. In fungi, dehydroquinase is part of a multifunctional enzyme which catalyzes five consecutive steps in the shikimate pathway. In aroD, it has been shown [1] that a histidine is involved in the catalytic mechanism; we used the region around this residue as a signature pattern.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Deka R.K. Kleanthous C. Coggins J.R. |
| Title | Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase. | |
| Source | J. Biol. Chem. 267:22237-22242(1992). | |
| PubMed ID | 1429576 |
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