PROSITE documentation PDOC00790
RNA polymerases M / 15 Kd subunits signature


In eukaryotes, there are three different forms of DNA-dependent RNA polymerases (EC transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consist of an oligomeric assemblage of 10 to 13 polypeptides.

It has recently been shown [1,2] that small subunits of about 15 Kd, found in polymerase types I and II, are highly conserved. Subunits known to belong to this family are:

  • Yeast RPA12 subunit from RNA polymerases I.
  • Yeast RPB9 subunit from RNA polymerase II.
  • Yeast RPC11 subunit from RNA polymerase III.
  • Mammalian RPB14.5 (gene POLR2I) from RNA polymerase II.
  • Drosophila RpII15 from RNA polymerase II.
  • Archebacterial RNA polymerase subunit M (gene rpoM).

These proteins contain a probable zinc finger in their N-terminal region and a C-terminal zinc ribbon domain (see <PDOC00383>). As a signature pattern for these subunits, we selected the region that contains the zinc finger.

Last update:

February 2024 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RNA_POL_M_15KD, PS01030; RNA polymerases M / 15 Kd subunits signature  (PATTERN)


1AuthorsAcker J. Wintzerith M. Vigneron M. Kedinger C.
TitleStructure of the gene encoding the 14.5 kDa subunit of human RNA polymerase II.
SourceNucleic Acids Res. 21:5345-5350(1993).
PubMed ID8265347

2AuthorsNogi Y. Yano R. Dodd J. Carles C. Nomura M.
TitleGene RRN4 in Saccharomyces cerevisiae encodes the A12.2 subunit of RNA polymerase I and is essential only at high temperatures.
SourceMol. Cell. Biol. 13:114-122(1993).
PubMed ID8417319

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