PROSITE documentation PDOC00817
Undecaprenyl pyrophosphate synthase family signature


Undecaprenyl pyrophosphate synthase (EC (UPP synthase) [1] generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). This bacterial enzyme is also found in archaebacteria; it is also related to the following uncharacterized proteins:

  • Yeast chromosome II hypothetical protein YBR002c.
  • Yeast chromosome XIII hypothetical protein YMR101c.
  • Schizosaccharomyces pombe hypothetical protein SpAC4D7.04c.
  • Mycobacterium tuberculosis hypothetical protein Rv1086.
  • A Corynebacterium glutamicum hypothetical protein in aroF 3'region.
  • A Streptomyces fradiae hypothetical protein in transposon Tn4556.

These are proteins of about 26 to 40 Kd whose central region is well conserved. They can be picked up in the database by the following pattern.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UPP_SYNTHASE, PS01066; Undecaprenyl pyrophosphate synthase family signature  (PATTERN)


1AuthorsApfel C.M. Takacs B. Fountoulakis M. Stieger M. Keck W.
TitleUse of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene.
SourceJ. Bacteriol. 181:483-492(1999).
PubMed ID9882662

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