PROSITE documentation PDOC00838
Uncharacterized protein family UPF0076 signature


The following uncharacterized proteins have been shown [1] to share regions of similarities:

  • Goat antigen UK114, a human homolog and the rat corresponding protein which is known as perchloric acid soluble protein (PSP1). PSP1 [2] may inhibit an initiation stage of cell-free protein synthesis.
  • Mouse heat-responsive protein HRSP12.
  • Yeast chromosome V hypothetical protein YER057c.
  • Yeast chromosome IX hypothetical protein YIL051c.
  • Caenorhabditis elegans hypothetical protein C23G10.2.
  • Escherichia coli hypothetical protein ycdK.
  • Escherichia coli hypothetical protein yhaR.
  • Escherichia coli hypothetical protein yjgF and HI0719, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yoaB.
  • Bacillus subtilis hypothetical protein yabJ.
  • Haemophilus influenzae hypothetical protein HI1627.
  • Helicobacter pylori hypothetical protein HP0944.
  • Lactococcus lactis aldR.
  • Myxococcus xanthus dfrA.
  • Synechocystis strain PCC 6803 hypothetical protein slr0709.
  • Rhizobium strain NGR234 symbiotic plasmid hypothetical protein y4sK.
  • Pyrococcus horikoshii hypothetical protein PH0854.

These are small proteins of around 15 Kd whose sequence is highly conserved. As a signature pattern, we selected a well conserved region located in the C-terminal part of these proteins.

Last update:

July 1999 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

UPF0076, PS01094; Uncharacterized protein family UPF0076 signature  (PATTERN)


1AuthorsBairoch A.
SourceUnpublished observations (1995).

2AuthorsOka T. Tsuji H. Noda C. Sakai K. Hong Y.-M. Suzuki I. Munoz S. Natori Y.
TitleIsolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis.
SourceJ. Biol. Chem. 270:30060-30067(1995).
PubMed ID8530410

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