We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00838Uncharacterized protein family UPF0076 signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00838
Description
The following uncharacterized proteins have been shown [1] to share regions of similarities:
- Goat antigen UK114, a human homolog and the rat corresponding protein which is known as perchloric acid soluble protein (PSP1). PSP1 [2] may inhibit an initiation stage of cell-free protein synthesis.
- Mouse heat-responsive protein HRSP12.
- Yeast chromosome V hypothetical protein YER057c.
- Yeast chromosome IX hypothetical protein YIL051c.
- Caenorhabditis elegans hypothetical protein C23G10.2.
- Escherichia coli hypothetical protein ycdK.
- Escherichia coli hypothetical protein yhaR.
- Escherichia coli hypothetical protein yjgF and HI0719, the corresponding Haemophilus influenzae protein.
- Escherichia coli hypothetical protein yoaB.
- Bacillus subtilis hypothetical protein yabJ.
- Haemophilus influenzae hypothetical protein HI1627.
- Helicobacter pylori hypothetical protein HP0944.
- Lactococcus lactis aldR.
- Myxococcus xanthus dfrA.
- Synechocystis strain PCC 6803 hypothetical protein slr0709.
- Rhizobium strain NGR234 symbiotic plasmid hypothetical protein y4sK.
- Pyrococcus horikoshii hypothetical protein PH0854.
These are small proteins of around 15 Kd whose sequence is highly conserved. As a signature pattern, we selected a well conserved region located in the C-terminal part of these proteins.
Last update:July 1999 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Bairoch A. |
| Source | Unpublished observations (1995). |
| 2 | Authors | Oka T. Tsuji H. Noda C. Sakai K. Hong Y.-M. Suzuki I. Munoz S. Natori Y. |
| Title | Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis. | |
| Source | J. Biol. Chem. 270:30060-30067(1995). | |
| PubMed ID | 8530410 |
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