PROSITE documentation PDOC00838

Uncharacterized protein family UPF0076 signature

The following uncharacterized proteins have been shown [1] to share regions of similarities:

• Goat antigen UK114, a human homolog and the rat corresponding protein which is known as perchloric acid soluble protein (PSP1). PSP1 [2] may inhibit an initiation stage of cell-free protein synthesis.
• Mouse heat-responsive protein HRSP12.
• Yeast chromosome V hypothetical protein YER057c.
• Yeast chromosome IX hypothetical protein YIL051c.
• Caenorhabditis elegans hypothetical protein C23G10.2.
• Escherichia coli hypothetical protein ycdK.
• Escherichia coli hypothetical protein yhaR.
• Escherichia coli hypothetical protein yjgF and HI0719, the corresponding Haemophilus influenzae protein.
• Escherichia coli hypothetical protein yoaB.
• Bacillus subtilis hypothetical protein yabJ.
• Haemophilus influenzae hypothetical protein HI1627.
• Helicobacter pylori hypothetical protein HP0944.
• Lactococcus lactis aldR.
• Myxococcus xanthus dfrA.
• Synechocystis strain PCC 6803 hypothetical protein slr0709.
• Rhizobium strain NGR234 symbiotic plasmid hypothetical protein y4sK.
• Pyrococcus horikoshii hypothetical protein PH0854.

These are small proteins of around 15 Kd whose sequence is highly conserved. As a signature pattern, we selected a well conserved region located in the C-terminal part of these proteins.