PROSITE documentation PDOC00841
Hydrogenases expression/synthesis hupF/hypC family signature


Bacterial membrane-bound nickel-dependent hydrogenases require a number of gene products for their expression and/or synthesis [1]. Among these genes, there is a group that codes for a family of small proteins (from 80 to 110 residues). The proteins that are known to belong to this family are:

  • Alcaligenes eutrophus and Azotobacter vinelandii hoxL and hypC.
  • Rhizobium leguminosarum and Rhodobacter capsulatus hupF and hypC.
  • Escherichia coli hypC and hybG.
  • Methanococcus jannaschii hypothetical protein MJ0200.

All these proteins start with a conserved Met-Cys dipeptide.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HUPF_HYPC, PS01097; Hydrogenases expression/synthesis hupF/hypC family signature  (PATTERN)


1AuthorsColbeau A. Richaud P. Toussaint B. Caballero F.J. Elster C. Delphin C. Smith R.L. Chabert J. Vignais P.M.
TitleOrganization of the genes necessary for hydrogenase expression in Rhodobacter capsulatus. Sequence analysis and identification of two hyp regulatory mutants.
SourceMol. Microbiol. 8:15-29(1993).
PubMed ID8497190

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