We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00844NNMT/PNMT/TEMT family of methyltransferases signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00844
Description
The following cytoplasmic vertebrate methyltransferases are evolutionary related [1,2]:
- Nicotinamide N-methyltransferase (EC 2.1.1.1) (NNMT). NNMT catalyzes the N- methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for the biotransformation of many drugs and xenobiotic compounds.
- Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMT). PNMT catalyzes the last step in catecholamine biosynthesis, the conversion of noradrenalin to adrenalin.
- Indolethylamine N-methyltransferase (EC 2.1.1.49) (INMT).
- Thioether S-methyltransferase (EC 2.1.1.96) (TEMT). TEMT catalyzes the methylation of dimethyl sulfide into trimethylsulfonium.
These enzymes use S-adenosyl-L-methionine as the methyl donor. They are proteins of 30 to 32 Kd. As a signature pattern we selected the most conserved region, a stretch of 16 residues which are located in the N-terminal section of these enzymes.
Last update:December 2001 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Aksoy S. Szumlanski C.L. Weinshilboum R.M. |
| Title | Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. | |
| Source | J. Biol. Chem. 269:14835-14840(1994). | |
| PubMed ID | 8182091 |
| 2 | Authors | Thompson M.A. Moon E. Kim U.-J. Xu J. Siciliano M.J. Weinshilboum R.M. |
| Title | Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. | |
| Source | Genomics 61:285-297(1999). | |
| PubMed ID | 10552930 | |
| DOI | 10.1006/geno.1999.5960 |
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