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PROSITE documentation PDOC00869
Rlu family of pseudouridine synthase signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00869

Description

The following proteins, which seems to belong to a family of pseudouridine synthases (EC 5.4.99.-) [1] have been shown to share regions of similarities:

  • Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase A (gene rluA). It is responsible for synthesis of pseudouridine from uracil-746 IN 23S rRNA.
  • Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase C (gene rluC). It is responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S rRNA.
  • Escherichia coli protein and homologs in other bacteria large subunit pseudouridine synthase D (gene rluD).
  • Yeast DRAP deaminase (gene RIB2).
  • Escherichia coli and Haemophilus influenzae tRNA pseudouridine synthase C (truC).
  • Haemophilus influenzae hypothetical protein HI0042.
  • Aquifex aeolicus hypothetical protein AQ_1758.
  • Bacillus subtilis hypothetical protein yhcT.
  • Bacillus subtilis hypothetical protein yjbO.
  • Bacillus subtilis hypothetical protein ylyB.
  • Helicobacter pylori hypothetical protein HP0347.
  • Helicobacter pylori hypothetical protein HP0745.
  • Helicobacter pylori hypothetical protein HP0956.
  • Mycoplasma genitalium hypothetical protein MG209.
  • Mycoplasma genitalium hypothetical protein MG370.
  • Synechocystis strain PCC 6803 hypothetical protein slr1592.
  • Synechocystis strain PCC 6803 hypothetical protein slr1629.
  • Yeast hypothetical protein YDL036c.
  • Yeast hypothetical protein YGR169c.
  • Fission yeast hypothetical protein SpAC18B11.02c.
  • Caenorhabditis elegans hypothetical protein K07E8.7.

These are proteins of from 21 to 50 Kd which contain a number of conserved regions in their central section. They can be picked up in the database by the following highly conserved pattern.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

PSI_RLU, PS01129; Rlu family of pseudouridine synthase signature  (PATTERN)


Reference

1AuthorsConrad J. Sun D. Englund N. Ofengand J.
TitleThe rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA.
SourceJ. Biol. Chem. 273:18562-18566(1998).
PubMed ID9660827



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