The following proteins, which seems to belong to a family of pseudouridine
synthases (EC 5.4.99.-) [1] have been shown to share regions of similarities:
Escherichia coli and Haemophilus influenzae ribosomal large subunit
pseudouridine synthase A (gene rluA). It is responsible for synthesis of
pseudouridine from uracil-746 IN 23S rRNA.
Escherichia coli and Haemophilus influenzae ribosomal large subunit
pseudouridine synthase C (gene rluC). It is responsible for synthesis of
pseudouridine from uracil at positions 955, 2504 and 2580 in 23S rRNA.
Escherichia coli protein and homologs in other bacteria large subunit
pseudouridine synthase D (gene rluD).
Yeast DRAP deaminase (gene RIB2).
Escherichia coli and Haemophilus influenzae tRNA pseudouridine synthase C
(truC).
Haemophilus influenzae hypothetical protein HI0042.
Aquifex aeolicus hypothetical protein AQ_1758.
Bacillus subtilis hypothetical protein yhcT.
Bacillus subtilis hypothetical protein yjbO.
Bacillus subtilis hypothetical protein ylyB.
Helicobacter pylori hypothetical protein HP0347.
Helicobacter pylori hypothetical protein HP0745.
Helicobacter pylori hypothetical protein HP0956.
Mycoplasma genitalium hypothetical protein MG209.
Mycoplasma genitalium hypothetical protein MG370.
Synechocystis strain PCC 6803 hypothetical protein slr1592.
Synechocystis strain PCC 6803 hypothetical protein slr1629.
Yeast hypothetical protein YDL036c.
Yeast hypothetical protein YGR169c.
Fission yeast hypothetical protein SpAC18B11.02c.
Caenorhabditis elegans hypothetical protein K07E8.7.
These are proteins of from 21 to 50 Kd which contain a number of conserved
regions in their central section. They can be picked up in the database by the
following highly conserved pattern.
PROSITE method (with tools and information) covered by this documentation:
Reference
1
Authors
Conrad J. Sun D. Englund N. Ofengand J.
Title
The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA.
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