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PROSITE documentation PDOC00869Rlu family of pseudouridine synthase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00869
Description
The following proteins, which seems to belong to a family of pseudouridine synthases (EC 5.4.99.-) [1] have been shown to share regions of similarities:
- Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase A (gene rluA). It is responsible for synthesis of pseudouridine from uracil-746 IN 23S rRNA.
- Escherichia coli and Haemophilus influenzae ribosomal large subunit pseudouridine synthase C (gene rluC). It is responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S rRNA.
- Escherichia coli protein and homologs in other bacteria large subunit pseudouridine synthase D (gene rluD).
- Yeast DRAP deaminase (gene RIB2).
- Escherichia coli and Haemophilus influenzae tRNA pseudouridine synthase C (truC).
- Haemophilus influenzae hypothetical protein HI0042.
- Aquifex aeolicus hypothetical protein AQ_1758.
- Bacillus subtilis hypothetical protein yhcT.
- Bacillus subtilis hypothetical protein yjbO.
- Bacillus subtilis hypothetical protein ylyB.
- Helicobacter pylori hypothetical protein HP0347.
- Helicobacter pylori hypothetical protein HP0745.
- Helicobacter pylori hypothetical protein HP0956.
- Mycoplasma genitalium hypothetical protein MG209.
- Mycoplasma genitalium hypothetical protein MG370.
- Synechocystis strain PCC 6803 hypothetical protein slr1592.
- Synechocystis strain PCC 6803 hypothetical protein slr1629.
- Yeast hypothetical protein YDL036c.
- Yeast hypothetical protein YGR169c.
- Fission yeast hypothetical protein SpAC18B11.02c.
- Caenorhabditis elegans hypothetical protein K07E8.7.
These are proteins of from 21 to 50 Kd which contain a number of conserved regions in their central section. They can be picked up in the database by the following highly conserved pattern.
Last update:April 2006 / Pattern revised.
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Reference
| 1 | Authors | Conrad J. Sun D. Englund N. Ofengand J. |
| Title | The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA. | |
| Source | J. Biol. Chem. 273:18562-18566(1998). | |
| PubMed ID | 9660827 |
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