PROSITE documentation PDOC00879Bacterial type II secretion system protein N signature
The secretion pathway (GSP) for the export of proteins (also called the type II pathway) [1] requires a number of protein components. One of them is known as the 'N' protein and has been sequenced in a variety of bacteria such as Aeromonas (gene exeN); Erwinia (gene outN); Klebsiella pneumoniae (gene pulN); or Vibrio cholerae (gene epsN).
The size of the 'N' protein is around 250 amino acids. It apparently contains a single transmembrane domain located in the N-terminal section. The short N-terminal domain is predicted to be cytoplasmic and the large C-terminal domain periplasmic. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins.
Last update:November 1995 / First entry.
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| 1 | Authors | Salmond G.P.C. Reeves P.J. |
| Title | Membrane traffic wardens and protein secretion in gram-negative bacteria. | |
| Source | Trends Biochem. Sci. 18:7-12(1993). | |
| PubMed ID | 8438237 |
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