PROSITE documentation PDOC00879
Bacterial type II secretion system protein N signature


The secretion pathway (GSP) for the export of proteins (also called the type II pathway) [1] requires a number of protein components. One of them is known as the 'N' protein and has been sequenced in a variety of bacteria such as Aeromonas (gene exeN); Erwinia (gene outN); Klebsiella pneumoniae (gene pulN); or Vibrio cholerae (gene epsN).

The size of the 'N' protein is around 250 amino acids. It apparently contains a single transmembrane domain located in the N-terminal section. The short N-terminal domain is predicted to be cytoplasmic and the large C-terminal domain periplasmic. As a signature pattern, we selected a conserved region in the N-terminal part of these proteins.

Last update:

November 1995 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

T2SP_N, PS01142; Bacterial type II secretion system protein N signature  (PATTERN)


1AuthorsSalmond G.P.C. Reeves P.J.
TitleMembrane traffic wardens and protein secretion in gram-negative bacteria.
SourceTrends Biochem. Sci. 18:7-12(1993).
PubMed ID8438237

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