PROSITE documentation PDOC00883
YrdC-like domain profile


The yrdC-like domain is an ~185-residue module which can be found in stand-alone form, or in association with other domains such as the acylphosphatase-like domain (see <PDOC00136>), the sua5-like domain, the hypF-like domain or the hypF-type zinc finger [1,2].

The yrdC-like domain folds into an α/β twisted open-sheet structure with parallel and antiparallel orientations of adjacent β-strands (see <PDB:1HRU>). The structure comprises seven α-helices and seven β-strands with an unusual order and topology of β-strands and very strong twisting between them. The yrdC-like domain features a large concave surface on one side that exhibits a positive electrostatic potential. The dimension of this depression, its curvature, and the fact that conserved basic amino acids are located at its floor suggest that it may be a nucleic acid binding domain [1].

Some proteins known to contain a yrdC-like domain are listed below:

  • Yeast protein SUA5. It has been identified as a suppressor of a translation initiation defect in cytochrome c and is required for normal growth.
  • Escherichia coli hypothetical protein yciO and HI1198, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein yrdC and HI0656, the corresponding Haemophilus influenzae protein.
  • Bacillus subtilis hypothetical protein ywlC.
  • Mycobacterium leprae hypothetical protein in rfe-hemK intergenic region.
  • Methanococcus jannaschii hypothetical protein MJ0062.

These are proteins of from 20 to 46 Kd.

The profile we developed covers the entire yrdC-like domain.

Last update:

November 2005 / Text revised; pattern removed and profile added.


Technical section

PROSITE method (with tools and information) covered by this documentation:

YRDC, PS51163; YrdC-like domain profile  (MATRIX)


1AuthorsTeplova M. Tereshko V. Sanishvili R. Joachimiak A. Bushueva T. Anderson W.F. Egli M.
TitleThe structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding.
SourceProtein Sci. 9:2557-2566(2000).
PubMed ID11206077

2AuthorsChen J. Ji C. Gu S. Zhao E. Dai J. Huang L. Qian J. Ying K. Xie Y. Mao Y.
TitleIsolation and identification of a novel cDNA that encodes human yrdC protein.
SourceJ. Hum. Genet. 48:164-169(2003).
PubMed ID12730717

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)