PROSITE documentation PDOC00930
Caveolins signature


Caveolins [1,2] are a family of integral membrane proteins which are the principal components of caveolae membranes. Cavoleae are flask-shaped plasma membrane invaginations whose exact cellular function is not yet clear. Caveolins may act as scaffolding proteins within caveolar membranes. They interact directly with G-protein α subunits and can functionally regulate their activity.

Currently, three different forms of caveolins are known: caveolin-1 (or VIP21), caveolin-2 and caveolin-3 (or M-caveolin).

Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. Structurally they seem to have a N-terminal and C-terminal hydrophilic segments and a long central transmembrane domains that probably forms an hairpin in the membrane. Both extremities are known to face the cytoplasm.

As a signature pattern, we selected a perfectly conseerved octapeptide which is located in the N-terminal section of caveolins.

Last update:

December 2001 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CAVEOLIN, PS01210; Caveolins signature  (PATTERN)


1AuthorsTang Z. Scherer P.E. Okamoto T. Song K. Chu K. Kohtz D.S. Nishimoto I. Lodish H.F. Lisanti M.P.
TitleMolecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle.
SourceJ. Biol. Chem. 271:2255-2261(1996).
PubMed ID8567687

2AuthorsScherer P.E. Okamoto T. Chun M. Nishimoto I. Lodish H.F. Lisanti M.P.
TitleIdentification, sequence, and expression of caveolin-2 defines a caveolin gene family.
SourceProc. Natl. Acad. Sci. U.S.A. 93:131-135(1996).
PubMed ID8552590

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