PROSITE documentation PDOC00930Caveolins signature
Caveolins [1,2] are a family of integral membrane proteins which are the principal components of caveolae membranes. Cavoleae are flask-shaped plasma membrane invaginations whose exact cellular function is not yet clear. Caveolins may act as scaffolding proteins within caveolar membranes. They interact directly with G-protein α subunits and can functionally regulate their activity.
Currently, three different forms of caveolins are known: caveolin-1 (or VIP21), caveolin-2 and caveolin-3 (or M-caveolin).
Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. Structurally they seem to have a N-terminal and C-terminal hydrophilic segments and a long central transmembrane domains that probably forms an hairpin in the membrane. Both extremities are known to face the cytoplasm.
As a signature pattern, we selected a perfectly conseerved octapeptide which is located in the N-terminal section of caveolins.
Last update:December 2001 / Pattern and text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Tang Z. Scherer P.E. Okamoto T. Song K. Chu K. Kohtz D.S. Nishimoto I. Lodish H.F. Lisanti M.P. |
| Title | Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. | |
| Source | J. Biol. Chem. 271:2255-2261(1996). | |
| PubMed ID | 8567687 |
| 2 | Authors | Scherer P.E. Okamoto T. Chun M. Nishimoto I. Lodish H.F. Lisanti M.P. |
| Title | Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996). | |
| PubMed ID | 8552590 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)