PROSITE documentation PDOC00932
ATP P2X receptors signature


P2X purinoreceptors [1,2] are cation-selective ion channels that open on binding to extracellular ATP; they play a role in fast synaptic transmission between neurones, and from autonomic nerves to smooth muscles. When ATP is released as a neurotransmitter from central and peripheral nerves it acts at P2X receptors to produce postsynaptic depolarization and excitation.

P2X receptors are from 397 to 595 amino acids long. They consist of a short intracellular N-terminus region followed by a transmembrane domain, a large extracellular loop that contains 10 conserved cysteines, a second transmembrane segment and a C-terminal intracellular tail.

Currently, seven forms (P2X1 to P2X7) of P2X receptors are known.

As a signature pattern, we selected a conserved region located in the central part of the extracellular domain and which contains two of the conserved cysteines.

Last update:

November 1997 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

P2X_RECEPTOR, PS01212; ATP P2X receptors signature  (PATTERN)


1AuthorsSurprenant A. Buell G.N. North R.A.
TitleP2X receptors bring new structure to ligand-gated ion channels.
SourceTrends Neurosci. 18:224-229(1995).
PubMed ID7541920

2AuthorsKennedy C. Leff P.
TitleHow should P2X purinoceptors be classified pharmacologically?
SourceTrends Pharmacol. Sci. 16:168-174(1995).
PubMed ID7624972

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