PROSITE documentation PDOC00933Protozoan/cyanobacterial globins signature
Description
Globins are heme-containing proteins involved in binding and/or transporting oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the only exceptions are the following proteins which form a family of their own [2,3,4]:
- Monomeric hemoglobins from the protozoan Paramecium caudatum, Tetrahymena pyriformis and Tetrahymena thermophila.
- Cyanoglobins from the cyanobacteria Nostoc commune and Synechocystis PCC 6803.
- Globins LI637 and LI410 from the chloroplast of the alga Chlamydomonas eugametos.
- Mycobacterium tuberculosis globins glbN and glbO.
These proteins contain a conserved histidine which could be involved in heme-binding. As a signature pattern, we use a conserved region that ends with this residue.
Last update:April 2006 / Pattern revised.
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References
| 1 | Source | Concise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter, Berlin New-York (1988). |
| 2 | Authors | Takagi T. |
| Source | Curr. Opin. Struct. Biol. 3:413-418(1993). |
| 3 | Authors | Couture M. Chamberland H. St-Pierre B. Lafontaine J. Guertin M. |
| Title | Nuclear genes encoding chloroplast hemoglobins in the unicellular green alga Chlamydomonas eugametos. | |
| Source | Mol. Gen. Genet. 243:185-197(1994). | |
| PubMed ID | 8177215 |
| 4 | Authors | Couture M. Das T.K. Savard P.Y. Ouellet Y. Wittenberg J.B. Wittenberg B.A. Rousseau D.L. Guertin M. |
| Title | Structural investigations of the hemoglobin of the cyanobacterium Synechocystis PCC6803 reveal a unique distal heme pocket. | |
| Source | Eur. J. Biochem. 267:4770-4780(2000). | |
| PubMed ID | 10903511 |
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