![]() |
|
PROSITE documentation PDOC00933 |
Globins are heme-containing proteins involved in binding and/or transporting oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the only exceptions are the following proteins which form a family of their own [2,3,4]:
These proteins contain a conserved histidine which could be involved in heme-binding. As a signature pattern, we use a conserved region that ends with this residue.
Last update:April 2006 / Pattern revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
1 | Source | Concise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter, Berlin New-York (1988). |
2 | Authors | Takagi T. |
Source | Curr. Opin. Struct. Biol. 3:413-418(1993). |
3 | Authors | Couture M. Chamberland H. St-Pierre B. Lafontaine J. Guertin M. |
Title | Nuclear genes encoding chloroplast hemoglobins in the unicellular green alga Chlamydomonas eugametos. | |
Source | Mol. Gen. Genet. 243:185-197(1994). | |
PubMed ID | 8177215 |
4 | Authors | Couture M. Das T.K. Savard P.Y. Ouellet Y. Wittenberg J.B. Wittenberg B.A. Rousseau D.L. Guertin M. |
Title | Structural investigations of the hemoglobin of the cyanobacterium Synechocystis PCC6803 reveal a unique distal heme pocket. | |
Source | Eur. J. Biochem. 267:4770-4780(2000). | |
PubMed ID | 10903511 |