We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00933Protozoan/cyanobacterial globins signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00933
Description
Globins are heme-containing proteins involved in binding and/or transporting oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the only exceptions are the following proteins which form a family of their own [2,3,4]:
- Monomeric hemoglobins from the protozoan Paramecium caudatum, Tetrahymena pyriformis and Tetrahymena thermophila.
- Cyanoglobins from the cyanobacteria Nostoc commune and Synechocystis PCC 6803.
- Globins LI637 and LI410 from the chloroplast of the alga Chlamydomonas eugametos.
- Mycobacterium tuberculosis globins glbN and glbO.
These proteins contain a conserved histidine which could be involved in heme-binding. As a signature pattern, we use a conserved region that ends with this residue.
Last update:April 2006 / Pattern revised.
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References
| 1 | Source | Concise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter, Berlin New-York (1988). |
| 2 | Authors | Takagi T. |
| Source | Curr. Opin. Struct. Biol. 3:413-418(1993). |
| 3 | Authors | Couture M. Chamberland H. St-Pierre B. Lafontaine J. Guertin M. |
| Title | Nuclear genes encoding chloroplast hemoglobins in the unicellular green alga Chlamydomonas eugametos. | |
| Source | Mol. Gen. Genet. 243:185-197(1994). | |
| PubMed ID | 8177215 |
| 4 | Authors | Couture M. Das T.K. Savard P.Y. Ouellet Y. Wittenberg J.B. Wittenberg B.A. Rousseau D.L. Guertin M. |
| Title | Structural investigations of the hemoglobin of the cyanobacterium Synechocystis PCC6803 reveal a unique distal heme pocket. | |
| Source | Eur. J. Biochem. 267:4770-4780(2000). | |
| PubMed ID | 10903511 |
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