PROSITE documentation PDOC00933
Protozoan/cyanobacterial globins signature


Globins are heme-containing proteins involved in binding and/or transporting oxygen [1]. Almost all globins belong to a large family (see <PDOC00793>), the only exceptions are the following proteins which form a family of their own [2,3,4]:

  • Monomeric hemoglobins from the protozoan Paramecium caudatum, Tetrahymena pyriformis and Tetrahymena thermophila.
  • Cyanoglobins from the cyanobacteria Nostoc commune and Synechocystis PCC 6803.
  • Globins LI637 and LI410 from the chloroplast of the alga Chlamydomonas eugametos.
  • Mycobacterium tuberculosis globins glbN and glbO.

These proteins contain a conserved histidine which could be involved in heme-binding. As a signature pattern, we use a conserved region that ends with this residue.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GLOBIN_FAM_2, PS01213; Protozoan/cyanobacterial globins signature  (PATTERN)


1SourceConcise Encyclopedia Biochemistry, Second Edition, Walter de Gruyter, Berlin New-York (1988).

2AuthorsTakagi T.
SourceCurr. Opin. Struct. Biol. 3:413-418(1993).

3AuthorsCouture M. Chamberland H. St-Pierre B. Lafontaine J. Guertin M.
TitleNuclear genes encoding chloroplast hemoglobins in the unicellular green alga Chlamydomonas eugametos.
SourceMol. Gen. Genet. 243:185-197(1994).
PubMed ID8177215

4AuthorsCouture M. Das T.K. Savard P.Y. Ouellet Y. Wittenberg J.B. Wittenberg B.A. Rousseau D.L. Guertin M.
TitleStructural investigations of the hemoglobin of the cyanobacterium Synechocystis PCC6803 reveal a unique distal heme pocket.
SourceEur. J. Biochem. 267:4770-4780(2000).
PubMed ID10903511

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