PROSITE documentation PDOC00938Phosphatidylethanolamine-binding protein family signature
Mammalian phosphatidylethanolamine-binding protein (also knowns as basic cytosolic 21 Kd protein) is a 186 residue protein found in a variety of tissues [1]. It binds hydrophobic ligands, such as phosphatidylethanolamine, but also seems [2] to bind nucleotides such as GTP and FMN, it is suggested that it could act in membrane remodeling during growth and maturation. This protein belongs to a family that also includes:
- Drosophila antennal protein A5, a putative odorant-binding protein.
- Onchocerca volvulus antigen Ov-16 and the related proteins D1, D2 and D3.
- Plasmodium falciparum putative phosphatidylethanolamine-binding protein.
- Toxocara canis secreted antigen TES-26. This larval protein has been shown to bind phosphatidylethanolamine.
- Yeast protein DKA1 (also known as NSP1 or TFS1). The function of this protein is not very clear.
- Yeast hypothetical protein YLR179C.
- Caenorhabditis elegans hypothetical protein F40A3.3.
- Plants proteins of the 'CENTRORADIALIS' and "SELF-PRUNING' family, some of which seem to be involved in the flowering process.
As a signature pattern, we selected the best conserved region which is located in the end of the first third of the sequence of these proteins.
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Seddiqi N. Bollengier F. Alliel P.M. Perin J.P. Bonnet F. Bucquoy S. Jolles P. Schoentgen F. |
| Title | Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues. | |
| Source | J. Mol. Evol. 39:655-660(1994). | |
| PubMed ID | 7807553 |
| 2 | Authors | Schoentgen F. Jolles P. |
| Title | From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site. | |
| Source | FEBS Lett. 369:22-26(1995). | |
| PubMed ID | 7641877 |
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