PROSITE documentation PDOC00948Glutamyl-tRNA(Gln) amidotransferase subunit B signature
Glutamyl-tRNA(Gln) amidotransferase subunit (EC 6.3.5.-) [1] is a microbial enzyme that furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated γ-phospho-Glu-tRNA(Gln). The enzyme is composed of three subunits: A (an amidase), B and C. It also exists in eukaryotes as a protein targeted to the mitochondria.
As a signature pattern, we selected a conserved region located in the N-terminal section of these proteins.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Curnow A.W. Hong K.-W. Yuan R. Kim S.I. Martins O. Winkler W. Henkin T.M. Soll D. |
| Title | Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 94:11819-11826(1997). | |
| PubMed ID | 9342321 |
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