Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00948Glutamyl-tRNA(Gln) amidotransferase subunit B signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00948
Glutamyl-tRNA(Gln) amidotransferase subunit (EC 6.3.5.-) [1] is a microbial enzyme that furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated γ-phospho-Glu-tRNA(Gln). The enzyme is composed of three subunits: A (an amidase), B and C. It also exists in eukaryotes as a protein targeted to the mitochondria.
As a signature pattern, we selected a conserved region located in the N-terminal section of these proteins.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Curnow A.W. Hong K.-W. Yuan R. Kim S.I. Martins O. Winkler W. Henkin T.M. Soll D. |
| Title | Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 94:11819-11826(1997). | |
| PubMed ID | 9342321 |
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