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PROSITE documentation PDOC00953
Dynein light chain type 1 signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00953

Description

Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits, intermediate size subunits and small subunits.

Among the small subunits, there is a family [1,2] of highly conserved proteins which consist of: 

  - Chlamydomonas reinhardtii flagellar outer arm dynein 8 Kd and 11 Kd  light
    chains.
  - Higher eukaryotes cytoplasmic dynein light chain 1.
  - Yeast cytoplasmic dynein light chain 1 (gene DYN2 or SLC1).
  - Caenorhabditis elegans hypothetical dynein light chains M18.2 and T26A5.9.

These proteins are have from 89 to 120 amino acids. As a signature pattern, we selected a highly conserved region.

Last update:

December 2001 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

DYNEIN_LIGHT_1, PS01239; Dynein light chain type 1 signature  (PATTERN)


References

1AuthorsKing S.M. Patel-King R.S.
TitleThe M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues.
SourceJ. Biol. Chem. 270:11445-11452(1995).
PubMed ID7744782

2AuthorsDick T. Ray K. Salz H.K. Chia W.
TitleCytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster.
SourceMol. Cell. Biol. 16:1966-1977(1996).
PubMed ID8628263



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