PROSITE documentation PDOC00953Dynein light chain type 1 signature
Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits, intermediate size subunits and small subunits.
Among the small subunits, there is a family [1,2] of highly conserved proteins which consist of:
- Chlamydomonas reinhardtii flagellar outer arm dynein 8 Kd and 11 Kd light
chains.
- Higher eukaryotes cytoplasmic dynein light chain 1.
- Yeast cytoplasmic dynein light chain 1 (gene DYN2 or SLC1).
- Caenorhabditis elegans hypothetical dynein light chains M18.2 and T26A5.9.
These proteins are have from 89 to 120 amino acids. As a signature pattern, we selected a highly conserved region.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | King S.M. Patel-King R.S. |
| Title | The M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues. | |
| Source | J. Biol. Chem. 270:11445-11452(1995). | |
| PubMed ID | 7744782 |
| 2 | Authors | Dick T. Ray K. Salz H.K. Chia W. |
| Title | Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. | |
| Source | Mol. Cell. Biol. 16:1966-1977(1996). | |
| PubMed ID | 8628263 |
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