PROSITE documentation PDOC00957Bax inhibitor-1 family signature
Description
Bax inhibitor-1 (BI-1) (gene TEGT) [1] is a suppressor of apoptosis that interacts with BCL2 and BCL-X. It is evolutionary related conserved and is found in all higher eukaryotes. It is also similar to the following proteins:
- Escherichia coli hypothetical protein yccA and HI0044, the corresponding Haemophilus influenzae protein.
- A probable Pseudomonas aeruginosa ortholog of yccA.
These are proteins of about 25 Kd which seem to contain seven transmembrane domains. We developed a signature pattern that correspond to a region that starts with the beginning of the third transmembrane domain and ends in the middle of the fourth one.
Last update:April 2006 / Pattern revised.
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Technical section
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Reference
| 1 | Authors | Xu Q. Reed J.C. |
| Title | Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. | |
| Source | Mol. Biol. Cell 1:337-346(1998). | |
| PubMed ID | 9660918 |
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