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PROSITE documentation PDOC00957

Bax inhibitor-1 family signature





Description

Bax inhibitor-1 (BI-1) (gene TEGT) [1] is a suppressor of apoptosis that interacts with BCL2 and BCL-X. It is evolutionary related conserved and is found in all higher eukaryotes. It is also similar to the following proteins:

  • Escherichia coli hypothetical protein yccA and HI0044, the corresponding Haemophilus influenzae protein.
  • A probable Pseudomonas aeruginosa ortholog of yccA.

These are proteins of about 25 Kd which seem to contain seven transmembrane domains. We developed a signature pattern that correspond to a region that starts with the beginning of the third transmembrane domain and ends in the middle of the fourth one.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BI1, PS01243; Bax inhibitor-1 family signature  (PATTERN)


Reference

1AuthorsXu Q. Reed J.C.
TitleBax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
SourceMol. Biol. Cell 1:337-346(1998).
PubMed ID9660918



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