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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE documentation PDOC00957
Bax inhibitor-1 family signature


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PURL: https://purl.expasy.org/prosite/documentation/PDOC00957

Description

Bax inhibitor-1 (BI-1) (gene TEGT) [1] is a suppressor of apoptosis that interacts with BCL2 and BCL-X. It is evolutionary related conserved and is found in all higher eukaryotes. It is also similar to the following proteins:

  • Escherichia coli hypothetical protein yccA and HI0044, the corresponding Haemophilus influenzae protein.
  • A probable Pseudomonas aeruginosa ortholog of yccA.

These are proteins of about 25 Kd which seem to contain seven transmembrane domains. We developed a signature pattern that correspond to a region that starts with the beginning of the third transmembrane domain and ends in the middle of the fourth one.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

BI1, PS01243; Bax inhibitor-1 family signature  (PATTERN)


Reference

1AuthorsXu Q. Reed J.C.
TitleBax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
SourceMol. Biol. Cell 1:337-346(1998).
PubMed ID9660918



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